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FLASH GENE
Symbol COG6 contributors: mct/ - updated : 05-09-2012
HGNC name component of oligomeric Golgi complex 6
HGNC id 18621
Corresponding disease
CDG2L congenital disorder of glycosylation, type 2L
Location 13q14.11      Physical location : 40.229.763 - 40.365.802
Synonym name
  • complexed with Dor1p 2
  • conserved oligomeric Golgi complex component 6
  • COG complex subunit 6
  • Synonym symbol(s) COD2, KIAA1134, DKFZp313D191, CDG2L
    DNA
    TYPE functioning gene
    STRUCTURE 136.04 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390395 13 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) BM-002 13q13.3 hypothetical protein BM-002 DKFZp686J0811 13q13.3 hypothetical protein DKFZp686J0811 LOC390396 13 similar to KIAA1074 protein STOML3 13q13.2 stomatin (EPB72)-like 3 FLJ12661 13q13.3 hypothetical protein FLJ12661 LOC387921 13 similar to RIKEN cDNA 8030451K01 LOC390397 13 similar to NTF2-related export protein 1 (p15 protein) LHFP 13q12 lipoma HMGIC fusion partner COG6 13q13.3 component of oligomeric golgi complex 6 FOXO1A 13q14.1 forkhead box O1A (rhabdomyosarcoma) MRPS31 13q13.2 mitochondrial ribosomal protein S31 SLC25A15 13q14 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 HCP34 13q14.11 cytochrome c, somatic pseudogene ELF1 13q13 E74-like factor 1 (ets domain transcription factor) WBP4 13q13.3 WW domain binding protein 4 (formin binding protein 21) KBTBD6 13q13.3 kelch repeat and BTB (POZ) domain containing 6 LOC390398 13 similar to calmodulin 1; Calmodulin 1 (phosphorylase kinase, delta) KBTBD7 13q13.3 kelch repeat and BTB (POZ) domain containing 7 MTRF1 13q14.1-q14.3 mitochondrial translational release factor 1 FLJ22054 13q13.3 hypothetical protein FLJ22054 LOC387922 13 similar to tubulin, beta 5
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 5257 - 615 - 2002 11980916
    19 - 3627 - 657 - 2002 11980916
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Visualeyelens   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text stem cells, placenta, fetal spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , oligo
    HOMOLOGY
    interspecies ortholog to murine Cog6
    ortholog to rattus Cog6
    Homologene
    FAMILY
  • COG6 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • required for normal golgi function
  • directly involved in trafficking and maintenance of Golgi glycosylation machinery
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the conserved oligomeric Golgi complex which is composed of eight different subunits
  • COG complex essentially formed by two subcomplexes, lobe A (COG1-4) and lobe B (COG5-8)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2L
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS