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FLASH GENE
Symbol COG5 contributors: mct/npt - updated : 20-02-2010
HGNC name component of oligomeric Golgi complex 5
HGNC id 14857
Corresponding disease
CDG2I congenital disorder of glycosylation type 2 I
Location 7q22.3      Physical location : 106.842.188 - 107.204.959
Synonym name
  • Golgi transport complex 1 (90 kDa subunit)
  • 13S Golgi transport complex 90 kDa subunit
  • conserved oligomeric Golgi complex component 5
  • Synonym symbol(s) GTC90, GOLTC1, GTC-90
    DNA
    TYPE functioning gene
    STRUCTURE 362.77 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389546 7 LOC389546 MLL5 7q22.1 myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) SRPK2 7q22 SFRS protein kinase 2 FLJ20485 7q22.2 hypothetical protein FLJ20485 FLJ11785 7q22.2 Rad50-interacting protein 1 LOC389547 7 hypothetical gene supported by M24070; NM_004559 KIAA1218 7q22.1 hypothetical gene supported by M24070; NM_004559 MGC33190 7q22.2 hypothetical protein MGC33190 FLJ23834 7q22.2 hypothetical protein FLJ23834 SYPL 7q22.1-q31.1 synaptophysin-like protein LOC392089 7 similar to DKFZP564O0463 protein; HSPC064 protein PBEF 7q11.23 similar to DKFZP564O0463 protein; HSPC064 protein FLJ36031 7q22.2 hypothetical protein FLJ36031 PIK3CG 7q21.11 phosphoinositide-3-kinase, catalytic, gamma polypeptide PRKAR2B 7q22-q31.1 protein kinase, cAMP-dependent, regulatory, type II, beta HBP1 7q22-q31 HMG-box transcription factor 1 COG5 7q31 component of oligomeric golgi complex 5 GPR22 7q22-q31.1 G protein-coupled receptor 22 PP35 7q22-q31 protein similar to E.coli yhdg and R. capsulatus nifR3 BCAP29 7q22-q31 B-cell receptor-associated protein 29 SLC26A4 7q31.1 solute carrier family 26, member 4 CBLL1 7q22.3 Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1 SLC26A3 7q33 solute carrier family 26, member 3 DLD 7q31-q32 dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex) LAMB1 7q22.1 laminin, beta 1 LAMB4 7q22-q31.2 laminin, beta 4 NRCAM 7q31.1-q31.2 neuronal cell adhesion molecule IPLA2(GAMMA) 7q31 intracellular membrane-associated calcium-independent phospholipase A2 gamma THAP5 7q22.3 THAP domain containing 5 DNAJB9 14q24.2-q24.3 DnaJ (Hsp40) homolog, subfamily B, member 9 LOC154907 7q22.3 hypothetical LOC154907
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 4880 94.9 860 - Loh, Oka (2005)
    22 - 4817 92.7 839 - Loh, Oka (2005)
    - - 5666 - 823 - Oka (2005)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus    
     intestinelarge intestinecolon  
     mouth    
    Reproductivefemale systemuteruscervix  
     male systemtestis   
    Respiratoryrespiratory tracttrachea  highly
     respiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , oligo
    HOMOLOGY
    Homologene
    FAMILY
  • COG5 family
  • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • regulating with COG3 diverse aspects of Golgi function, including transport from the ER to the Golgi apparatus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the conserved oligomeric Golgi complex which is composed of eight different subunits
  • COG complex essentially formed by two subcomplexes, lobe A (COG1-4) and lobe B (COG5-8)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2I
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS