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FLASH GENE
Symbol COG1 contributors: npt - updated : 07-05-2011
HGNC name component of oligomeric golgi complex 1
HGNC id 6545
Corresponding disease
CCMLS cerebrocostomandibular-like syndrome
CDG2G congenital disorder of glycosylation, type 2G
Location 17q25.1      Physical location : 71.189.172 - 71.204.643
Synonym name
  • low density lipoprotein receptor defect B complementing
  • conserved oligomeric Golgi complex component 1
  • COG complex subunit 1
  • Synonym symbol(s) LDLB, KIAA1381, DKFZp762L1710
    DNA
    TYPE functioning gene
    STRUCTURE 15.47 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3035 - 980 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrainforebraincerebral cortexfrontal cortex 
     brainlimbic systemhippocampus  
    Reproductivemale systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , oligo
    HOMOLOGY
    interspecies ortholog to murine Cog1
    Homologene
    FAMILY
  • COG1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates
  • playing a role in the organization of the Golgi-localized complex
  • involved in controlling vesicular retrograde transport of Golgi resident proteins throughout the Golgi apparatus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the conserved oligomeric Golgi complex which is composed of eight different subunits
  • COG complex essentially formed by two subcomplexes, lobe A (COG1-4) and lobe B (COG5-8)
  • COG1, COG2, COG3, COG4, form a stable core complex potentially sufficient to support wild-type growth and reasonably efficient retrograde trafficking
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2G , CCMLS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS