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FLASH GENE
Symbol COG1 contributors: npt - updated : 07-05-2011
HGNC name component of oligomeric golgi complex 1
HGNC id 6545
Corresponding disease
CCMLS cerebrocostomandibular-like syndrome
CDG2G congenital disorder of glycosylation, type 2G
Location 17q25.1      Physical location : 71.189.172 - 71.204.643
Synonym name
  • low density lipoprotein receptor defect B complementing
  • conserved oligomeric Golgi complex component 1
  • COG complex subunit 1
  • Synonym symbol(s) LDLB, KIAA1381, DKFZp762L1710
    DNA
    TYPE functioning gene
    STRUCTURE 15.47 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388416 17 LOC388416 SOX9 17q24.3-q25.1 SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal) LOC388417 17 LOC388417 SLC39A11 17q25.1 solute carrier family 39 (metal ion transporter), member 11 LOC390811 17 similar to DNA-directed RNA polymerases III 12.5 kDa polypeptide (RNA polymerase III C11 subunit) (HsC11p) (hRPC11) (My010 protein) SSTR2 17q24.3-q25 somatostatin receptor 2 COG1 17q25.1 component of oligomeric golgi complex 1 FLJ14775 17q25.1 hypothetical protein FLJ14775 HLC-8 17q25.1 lung cancer-related protein 8 LOC390812 17 similar to cleavage and polyadenylation specific factor 4; musculus clipper/cleavage and polyadenylation specificity factor 30 kDa subunit; cleavage and polyadenylation specific factor 4, 30kD subunit CDC42EP4 17q24-q25 CDC42 effector protein (Rho GTPase binding) 4 SDK2 17q21.31 sidekick homolog 2 (chicken) LOC388418 17 hypothetical gene supported by AL833395 FLJ40319 17q25.2 hypothetical protein FLJ40319 RPL38 17q22 ribosomal protein L38 TTYH2 17q24 Tweety homolog 2 (Drosophila) DNAI2 17q25 dynein, axonemal, intermediate polypeptide 2 FLJ37300 17q25.2 hypothetical protein FLJ37300 LOC388419 17 similar to galectin 3 binding protein; L3 antigen; Mac-2-binding protein; serum protein 90K GPR142 17q25.2 G protein-coupled receptor 142
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3035 - 980 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrainforebraincerebral cortexfrontal cortex 
     brainlimbic systemhippocampus  
    Reproductivemale systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , oligo
    HOMOLOGY
    interspecies ortholog to murine Cog1
    Homologene
    FAMILY
  • COG1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates
  • playing a role in the organization of the Golgi-localized complex
  • involved in controlling vesicular retrograde transport of Golgi resident proteins throughout the Golgi apparatus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the conserved oligomeric Golgi complex which is composed of eight different subunits
  • COG complex essentially formed by two subcomplexes, lobe A (COG1-4) and lobe B (COG5-8)
  • COG1, COG2, COG3, COG4, form a stable core complex potentially sufficient to support wild-type growth and reasonably efficient retrograde trafficking
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2G , CCMLS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS