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FLASH GENE
Symbol COBL contributors: mct - updated : 25-09-2018
HGNC name cordon-bleu WH2 repeat protein
HGNC id 22199
Location 7p12.1      Physical location : 51.083.909 - 51.384.515
Synonym name
  • cDNA sequence,expressed in brain, >100kDa,related to murine cordon bleu
  • protein cordon-bleu
  • Synonym symbol(s) KIAA0633, DKFZp686G13227, MGC131893
    DNA
    TYPE functioning gene
    STRUCTURE 300.65 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 5369 135.5 1261 - 2011 21816349
    12 - 5105 - 1173 - 2011 21816349
    13 - 5228
    13 - 5276 - 1230 - 2011 21816349
    14 - 5400 - 1271 - 2011 21816349
    8 - 2454 - 469 - 2011 21816349
    8 - 3909 - 379 - 2011 21816349
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal COBL domain, binding several BAR-containing proteins, including SNX9, PACSIN 2/syndapin 2, and ASAP1
  • three C-terminal WH2 domains, WH2 repeats that confer multifunctional regulation of actin dynamics, which makes COBL a dynamizer of actin assembly
  • HOMOLOGY
    interspecies homolog to murine cordon bleu
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nuclear envelope
    text
  • has a very specific localization in epithelial cells at the basal region of microvilli, a localization unlikely to be involved in actin nucleation
  • localizes to the base of brush border (BB) microvilli via a mechanism that requires its proline-rich N-terminus
  • basic FUNCTION
  • COBL is an actin nucleator controlling neuronal morphology and development
  • SPIRE1, SPIRE2, and COBL can synergize with other actin regulators
  • is a novel WH2 domain-based actin nucleator
  • COBL and PACSIN1 work together in dendritic arbor development
  • COBL and SPIRE1, SPIRE2 display different functions by selecting different sets of the multifunctional properties of WH2 domains
  • the formation of distinct types of ciliary structures relies on membrane topology-modulating mechanisms that are based on F-BAR domain functions and on complex formation of PACSIN1 with the actin nucleator COBL
  • ciliated sensory hair cell formation and function require the F-BAR protein PACSIN1 and the WH2 domain-based actin nucleator COBL
  • F-actin-anchored COBL/DBNL complexes seem crucial for neuromorphogenesis processes, particularly for the postnatal arborization of Purkinje cells representing the source for all motor coordination in the cerebellar cortex
  • is a regulator of actin dynamics in neural development and ciliogenesis
  • plays some role in early arborization of neurons and nucleates actin by a mechanism that requires a combination of all three of its actin monomer-binding WH2 domains
  • is a multifunctional WASP-Homology 2 (WH2) domain-containing protein implicated in a wide variety of cellular functions ranging from dendritic arborization in neurons to the assembly of microvilli on the surface of transporting epithelial cell
  • COBL induces the formation of dynamic linear actin structures throughout the cytosol, and contributes to the assembly of actin-based structures such as epithelial microvilli
  • actin nucleator COBL is critical for neuronal morphogenesis
  • COBL-dependent planar cell polarity maintenance and refinement processes seem critical for hearing
  • actin nucleator COBL is an important effector in postnatal refinement and maintenance of planar cell polarity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • COBL-mediated dendritic branch induction in hippocampal neurons critically relied on DBNL
  • COBL acts downstream of the F-BAR protein PACSIN2, which drives COBL targeting to the apical domain
  • COBL-mediated dendritic arborization required PRMT2, complex formation with PRMT2, and PRMT2 catalytic activity
  • cell & other
    REGULATION
    Other is regulated by Ca2+ and multiple, direct associations of the Ca2+ sensor Calmodulin (CaM)
    is controlled by arginine methylation, and COBL methylation is key for COBL actin binding
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS