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FLASH GENE
Symbol CNTLN contributors: mct - updated : 20-02-2018
HGNC name centlein, centrosomal protein
HGNC id 23432
Location 9p22.2      Physical location : 17.135.037 - 17.503.915
Synonym name
  • chromosome 9 open reading frame 39
  • centlein
  • Synonym symbol(s) FLJ20276, C9orf101, FLJ25636, C9orf39, bA340N12.1, RP11-340N12.1
    DNA
    TYPE functioning gene
    STRUCTURE 376.03 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 5582 161.6 1406 - 2008 18086554
    7 - 4936 - 391 - 2008 18086554
    3 - 2269 - 203 - 2008 18086554
    3 - 2080 - 140 - 2008 18086554
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Nervousnerve   highly
    Reproductivefemale systemovary   
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Rho-associated coiled coil region
  • HOMOLOGY
    interspecies ortholog to rattus LOC313331
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    text
  • localized at centrosomes in interphase and mitosis
  • centriolar protein, localizing to the proximal ends of the centrioles
  • basic FUNCTION
  • including aphidicolin-inducible common fragile site FRA9G and involved in signal transduction
  • is a widespread centrosomal protein and its association with centrosomes is independent of microtubules
  • appeared to be enriched in the mother centriole in G1 phase, suggesting possible involvement of centlein in mother-centriole-related functions, such as duplication of centrioles and generation of primary cilia
  • centriolar protein CNTLN functions as a molecular link between CEP250 and CEP68 to maintain centrosome cohesion
  • is involved in microtubules stability and neuritogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • centrosome cohesion is maintained by the newly identified complex of CEP250-CNTLN-CEP68
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CNTLN localizes to the proximal ends of the centrioles and directly interacts with both CEP250 and CEP68
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS