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FLASH GENE
Symbol CNST contributors: mct/npt - updated : 19-04-2010
HGNC name consortin, connexin sorting protein
HGNC id 26486
Location 1q44      Physical location : 246.729.638 - 246.831.883
Synonym name
  • hypothetical protein LOC163882
  • chromosome 1 open reading frame 71
    • Synonym symbol(s) FLJ32001, MGC18089, RP11-452J6.1, C1orf71
    DNA
    TYPE functioning gene
    STRUCTURE 102.25 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 5233 79.5 725 - Lampe (2010)
    9 - 2562 67.4 616 - Lampe (2010)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
    Lymphoid/Immunetonsils    
    Respiratoryrespiratory tracttrachea  predominantly
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putatively cytosolic, N-terminal segment which includes the connexin-interacting region and is highly disordered
  • short C-terminal tail well structured and likely to form a globular domain (Del Castillo 2010)
    • HOMOLOGY
    Homologene
    FAMILY
  • CNST family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text located at the trans-Golgi network (TGN), in tubulovesicular transport organelles, and at the plasma membrane (Del Castillo 2010)
    basic FUNCTION
  • role in the intracellular sorting of connexins, acts as a TGN receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (Del Castillo 2010)
  • first cargo receptor implicated in the traffic of integral membrane proteins (Del Castillo 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with the TGN clathrin adaptors GGA1 and GGA2 (Del Castillo 2010)
  • binding partner of connexins, the building blocks of gap junctions (Del Castillo 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS