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FLASH GENE
Symbol CNRIP1 contributors: mct/npt - updated : 13/11/2008
HGNC name cannabinoid receptor interacting protein 1
HGNC id 24546
Location 2p14      Physical location : 68.511.303 - 68.547.183
Synonym name chromosome 2 open reading frame 32
Synonym symbol(s) CRIP1, CRIP1a, CRIP1b, C2orf32, DKFZP566K1924
DNA
TYPE functioning gene
STRUCTURE 35.88 kb     3 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 splicing 2037 18.5 164 - Niehaus (2007)
  • also known as CRIP1a
  • suppressing cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels
    • 3 splicing 1312 14.1 128 - Niehaus (2007)
  • also known as CRIP1b
  • using an alternate exon in the 3' coding region compared to variant 1
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Nervousbrain   moderately
     nerve   predominantly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Cnrip1 (95.7 pc)
    homolog to murine Cnrip1 (96.3 pc)
    Homologene
    FAMILY
  • CNRIP family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in synaptic plasticity, analgesia, appetite, and neuroprotection
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the C-terminal tail of cannabinoid receptor CNR1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS