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FLASH GENE
Symbol CNR1 contributors: mct/npt - updated : 09-07-2016
HGNC name cannabinoid receptor 1 (brain)
HGNC id 2159
Location 6q15      Physical location : 88.849.586 - 88.875.767
Synonym name central cannabinoid receptor
Synonym symbol(s) CNR, CB1R, CB1A, CANN6, CB1K5, CB-R, CB1,
DNA
TYPE functioning gene
STRUCTURE 26.18 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
HTR1E 6q14-q15 5-hydroxytryptamine (serotonin) receptor 1E CGA 6q12-q21 glycoprotein hormones, alpha polypeptide LOC391950 6 similar to Reticulocalbin 1 precursor LOC389415 6 LOC389415 ZNF292 6q15 zinc finger protein 292 GJB7 6q15 gap junction protein, beta 7 C6orf162 6q15-q16.1 chromosome 6 open reading frame 162 C6orf163 6q15 chromosome 6 open reading frame 163 C6orf165 6q15 chromosome 6 open reading frame 165 TAF13P 6q14.3-15 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, pseudogene SLC35A1 6q16.1 solute carrier family 35 (CMP-sialic acid transporter), member A1 RARSL 6q16.1 arginyl-tRNA synthetase-like ORC3L 6q14.3-16.3 origin recognition complex, subunit 3-like (yeast) C6orf166 6q15 chromosome 6 open reading frame 166 SPACA1 6q16.1 sperm acrosome associated 1 CNR1 6q14-q15 cannabinoid receptor 1 (brain) LOC391951 6 similar to ribosomal protein S14 ACTBP8 6q13 actin, beta pseudogene 8 RNGTT 6q16 RNA guanylyltransferase and 5'-phosphatase HCP16 6q15 cytochrome c, somatic pseudogene PNRC1 6q16.1 proline-rich nuclear receptor coactivator 1 SRrp35 6q16.1 serine-arginine repressor protein (35 kDa) ACY1L2 6q16.1 aminoacylase 1-like 2 GABRR1 6q13-q15.3 gamma-aminobutyric acid (GABA) receptor, rho 1 GABRR2 6q14-q16.3 gamma-aminobutyric acid (GABA) receptor, rho 2 UBE2J1 6q16.1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) RRAGD 6q15-q16 Ras-related GTP binding D ANKRD6 6q14.2-q16.1 ankyrin repeat domain 6 DJ122O8.2 6q14.2-q16.1 hypothetical protein dJ122O8.2 MDN1 6q15 MDN1, midasin homolog (yeast)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 5732 52.8 472 - 2008 18285348
  • CNR1 Ia
  • 2 - 5387 - 439 - 2008 18285348
    CNR1 Ib
    3 - 5863 52.8 472 - 2008 18285348
    4 - 5901 52.8 472 - 2008 18285348
    2 - 5776 52.8 472 - 2008 18285348
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Lymphoid/Immunelymph node   highly
    Nervousbrain   predominantly Homo sapiens
    Urinarykidneytubulecollecting duct   Homo sapiens
     kidneytubuleconvoluted tubule   Homo sapiens
    Visualeyeanterior segmentcornea  
     eyeuveaciliary body  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    Muscularstriatum  highly
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text
  • expressed in the subventricular zone and in Cajal-Retzius cells in the molecular zone of the developing neocortex
  • expression in fetal and adult kidneys
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • C-terminus, having critical structures that are important for CB(1) activity and regulation
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • inhibiting adenylate cyclase located in and/or one cone pedicles and rod spherules
  • also inhibiting voltage-gated L-type calcium channel current in retinal bipolar cells
  • putatively involved for endogenous cannabinoid system in retinal physiology
  • play an unexpected role in dorsal horn pain-controlling circuits
  • participated in the regulation of lipid metabolism in human-derived immortalized hepatocytes by regulating the expression of key enzymes of lipid synthesis and transport
  • potential function in the early stages of corticogenesis
  • having a role in the regulation of bone mass
  • responsible for the psychotropic action of cannabinoids
  • could play an instrumental role in the development and function of the retina (
  • seems to be involved in the regulation of the EP300 wave as a marker of selective attention and working memory
  • its activity on hippocampal GABAergic neurons protects against age-dependent cognitive decline by reducing pyramidal cell degeneration and neuroinflammation
  • role of CNR1 in the regulation of Neural stem cells (NSCs) fate, suggesting that its activation may represent a pro-neuronal differentiation signal
  • endogenous CNR1 activation contributes to vascular SMC proliferation and neointima formation in response to arterial injury
  • play a critical role in LPS-induced febrile responses through inhibiting TLR4-mediated cytokine production
  • dependent control of cortical feedback projections in olfactory circuits couples internal states to perception and behavior
  • is not only associated with phenotypes such as cognitive performance, addiction and anxiety, but is also known to be crucially involved in responses to acute and chronic psychological and cellular stress conditions
  • has a major role in the activation of myofibroblasts
  • possibility of crosstalk between SST subtypes and CNR1 in regulation of physiological activities in the hippocampus
  • participate in the homeostatic responses regulating fluid balance and energy homeostasis during water deprivation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • CNR1 signaling may thus play a role in physiological cardiorespiratory regulation and protect from some adverse cardiovascular consequences of a high-fat diet (HFD)
  • CNR1 signaling contributes to the hyperglycemia disturbance of PPARG2 signaling and increases inflammatory cytokine secretion and fibrotic matrix deposition in renal glomeruli
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • tight control of CNR1 function by ADORA2A in glutamatergic terminals of the striatum
  • receptor binding &
  • 916;(9)-tetrahydrocannabinol, and implicated in several disease states, including drug addiction, anxiety, depression, obesity, and chronic pain
  • binding between a distal C-terminus fragment of cannabinoid receptor 1 CNR1) and arrestin-2 (ARRB2) (
  • ADORA2A and CNR1 may physically and functionally interact
  • CNR1 activation did not engage the key regulator of skin pigmentation, cyclic AMP, showing a major difference compared with the regulation of melanogenesis by alpha-melanocyte-stimulating hormone through MC1R
  • HINT1 protein cooperates with CNR1 to negatively regulate glutamate NMDA receptor activity
  • assembles with multiple members of the WASL complex and the RhoGTPase RAC1 and modulates their activity
  • cell & other
    REGULATION
    Other RARgamma regulates CNR1 expression and is thus involved in the control of hepatic fat metabolism by endocannabinoids
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in clear cell renal cell carcinoma
    constitutional     --over  
    might cause abnormal decidualization and impair trophoblast invasion, thus being involved in the pathogenesis of preeclampsia
    constitutional       loss of function
    alleviates diabetes-mediated renal deterioration
    Susceptibility
  • to anorexia nervosa
  • to obesity related phenotypes
  • to hebephrenic schizophrenia
  • to sensitivity to the acute effects of cannabinoids on EP300 generation in healthy subjects
  • to diabetic nephropathy and diabetic retinopathy in patients with T2DM
  • Variant & Polymorphism other
  • variant increasing the risk of obesity related phenotypes
  • variant increasing the risk of hebephrenic schizophrenia
  • variations within CNR1 may differentially alter the sensitivity to the acute effects of cannabinoids on EP300 generation in healthy subjects
  • association of the G1359A polymorphism with diabetic nephropathy and diabetic retinopathy in patients with T2DM
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    treatment of osteoporosis and other bone diseases (antagonists of CNR1)
    digestive  
    use of cannabinoid CB(1) receptors in parietal cells as new therapeutic targets for the regulation of gastric acid production
    diabetetype 1 
    CNR1 inhibition may be beneficial in the treatment of diabetic retinopathy, a devastating complication of diabetes
    miscelleaneousurinarychronic kidney disease
    may be a new target for treating chronic kidney disease
    ANIMAL & CELL MODELS
  • mice lacking the Cnr1 gene, showed an accelerated age-dependent deficit in spatial learning accompanied by a loss of principal neurons in the hippocampus (