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FLASH GENE
Symbol CNPY4 contributors: mct/npt - updated : 09-02-2016
HGNC name canopy 4 homolog (zebrafish)
HGNC id 28631
Location 7q22.1      Physical location : 99.717.264 - 99.723.126
Synonym name
  • protein associated with Tlr4
  • CDNA PSEC0237 fis, clone HEMBA1007186, weakly similar to Homo sapiens
  • CTG4a mRNA
  • Synonym symbol(s) MGC40499, PRAT4B, GPVR1909, tcag7.626
    DNA
    TYPE functioning gene
    STRUCTURE 5.87 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1547 28.3 248 - 2006 16338228
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide followed by a mature peptide
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • regulates cell surface expression of TLR4
  • distinct roles for CNPY3 and CNPY4 in the regulation of TLR1 surface expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ER-resident TLR chaperones, CNPY3, CNPY4 act as positive and negative regulators of TLR1 surface trafficking, respectively
  • positively regulates TLR4 surface expression but plays a negatively regulatory role in the surface expression of TLR1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS