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FLASH GENE
Symbol CNPY2 contributors: mct - updated : 25-01-2014
HGNC name canopy 2 homolog (zebrafish)
HGNC id 13529
Location 12q13.2      Physical location : 56.704.214 - 56.710.128
Synonym name
  • transmembrane protein 4
  • MIR-interacting saposin-like protein
  • putative secreted protein ZSIG9
  • Synonym symbol(s) MSAP, ZSIG9, HP10390, TMEM4
    DNA
    TYPE functioning gene
    STRUCTURE 5.92 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1247 20 182 - -
    3 - 1149 - 84 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselsaorta   
    Endocrinepancreas    
    Nervousbrainbasal nuclei  highly Homo sapiens
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a saposin-like domain
  • four AA sequence at the C-terminal end that resembles the classical KDEL motif for ER retention
  • HOMOLOGY
    Homologene
    FAMILY
  • Canopy gene family of saposin-like proteins (SAPLIPs)
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • co-localized in cell lines and in primary neurons
  • type-2 transmembrane protein
  • basic FUNCTION
  • involved in ubiquitin-dependent protein catabolism
  • positive regulator of neurite outgrowth
  • can stabilize myosin regulatory light chain (MRLC) and thus bring about an increase in neurite outgrowth
  • important role of FGF21 and CNPY2 in the regulation of LDLRs
  • constitutes a natural inhibitor/blocker of MYLIP activity in different systems
  • is an important regulator of LDLR levels in human hepatocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the ezrin-radixin-moesin (ERM)-like myosin regulatory light chain-interacting protein (MIR), and the two proteins are co-localized in cell lines and in primary neurons
  • acts in conjunction with MYLIP, inhibiting its effects on LDLR degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS