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FLASH GENE
Symbol CNP contributors: mct - updated : 10-07-2006
HGNC name 2',3'-cyclic nucleotide 3' phosphodiesterase
HGNC id 2158
Location 17q21      Physical location : 40.118.758 - 40.129.754
Synonym symbol(s) CNP1, CN37
EC.number 3.1.4.37
DNA
TYPE functioning gene
STRUCTURE 11.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Physical map
KRTHA5 17q12-q21 keratin, hair, acidic, 5 KRTHA6 17q12-q21 keratin, hair, acidic, 6 KRT13 17q21-q22 keratin 13 KRT15 17q21.2 keratin 15 KRT19 17q21 keratin 19 KRT9 17q21.1-q21.2 keratin 9 (epidermolytic palmoplantar keratoderma) KRT14 17q21-q22 keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) KRT16 17q21-q22 keratin 16 (focal non-epidermolytic palmoplantar keratoderma) KRT17 17q21-q22 keratin 17 LOC388385 17 LOC388385 SUI1 17q21.31 putative translation initiation factor GAS 17q21-q21.2 gastrin HAP1 17q21.2-q21.3 huntingtin-associated protein 1 (neuroan 1) JUP 17q21 junction plakoglobin SC65 17q21.31 synaptonemal complex protein SC65 FKBP10 17q21.1 FK506 binding protein 10, 65 kDa MGC20781 17q21.31 hypothetical protein MGC20781 KLHL10 17q21.2 kelch-like 10 (Drosophila) FLJ10572 17q21.31 hypothetical protein FLJ10572 ACLY 17q21-q22 ATP citrate lyase DKFZP434H0115 17q21.31 hypothetical protein DKFZp434H0115 CNP 17q21 2',3'-cyclic nucleotide 3' phosphodiesterase DNAJC7 17q11.2 DnaJ (Hsp40) homolog, subfamily C, member 7 KBRAS2 17q21.31 I-kappa-B-interacting Ras-like protein 2 LOC201181 17q21.31 similar to hypothetical protein A930006D11 LOC390796 17 similar to hypothetical protein A930006D11 LGP2 17q21.2 similar to hypothetical protein A930006D11 GCN5L2 17q21 GCN5 general control of amino-acid synthesis 5-like 2 (yeast) HspB9 17q21.31 small heat shock protein B9 RAB5C 17q21 RAB5C, member RAS oncogene family KCNH4 17q21.31 potassium voltage-gated channel, subfamily H (eag-related), member 4 HCRT 17q21 hypocretin (orexin) neuropeptide precursor LGP1 17q21.2 hypocretin (orexin) neuropeptide precursor STAT5B 17q11.2 signal transducer and activator of transcription 5B
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 5222 47.6 421 - Lappe-Siefke, Tang (2007)
- initiation site - 46 401 . at much lower levels in non-myelinating tissues . localized specifically to mitochondria in non-myelinating cells Lappe-Siefke, Lee (2006)
  • differs from CNP1 by a 20 amino acid N-terminal extension and is also expressed at much lower levels in non-myelinating tissues
  • translocated to mitochondria by virtue of a mitochondrial targeting signal at the N-terminus
  • having a mitochondrial function in glial and non-glial cells
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Nervousbrain   highly
     spinal cord    
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoligodendrocyte
    NervousSchwann cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling neurotransmitter
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in synaptic transmission
  • playing an essential role in axonal survival but not in myelin assembly, coupling oligodendroglial functions in axonal support and myelination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein mitochondria and cytoskeletal proteins in certain non-glial cells
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS