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FLASH GENE
Symbol CNOT8 contributors: mct/npt/pgu - updated : 02-09-2020
HGNC name CCR4-NOT transcription complex, subunit 8
HGNC id 9207
Location 5q33.2      Physical location : 154.238.197 - 154.256.351
Synonym name
  • POP2 (yeast homolog)
  • carbon catabolic repressor protein (CCR4) associative factor 1
  • cellular pyrin domain-only protein 2
  • CAF1-like protein
  • PGK promoter directed over production
  • Synonym symbol(s) CAF1, POP2, CALIF, CAF2
    EC.number 3.1.13.4
    DNA
    TYPE functioning gene
    STRUCTURE 18.84 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D5S410 - CNOT8 - D5S487 - qter
    Authors Fidler (99)
    regionally located localized in the critical region of 5q-syndrome
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2494 33.5 292 - 2015 25944446
    5 - 2265 - 186 - 2015 25944446
    6 - 2145 - 186 - 2015 25944446
    6 - 2300 - 186 - 2015 25944446
    7 - 2446 - 292 - 2015 25944446
    6 - 2284 - 238 - 2015 25944446
    7 - 2358 - 186 - 2015 25944446
    5 - 2095 - 128 - 2015 25944446
    6 - 2257 - 186 - 2015 25944446
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three glutamine stretches
  • a proline-rich region
  • a serine/threonine rich region
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae
    Homologene
    FAMILY
  • CAF1 family
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • negative control of cell proliferation associated with cell-cell contact through interaction with BTG1
  • deadenylase interacting with TOB1 that is involved in the general mechanism of mRNA decay by mediating mRNA deadenylation
  • CNOT7/8 catalytic subunits are essential for deadenylation, which is necessary to maintain cell viability, whereas CNOT6/6L are not
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CCR4-NOT (CAF1) complex involved in the control of gene expression
  • complex of BTG4 and CNOT7, CNOT8 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with BTG1 (potential tumor suppressor), driving the formation of CAF1 complex with NOTs proteins
  • binds to PYCARD and NLRP2, thereby blocking formation of cryopyrin and NLRP2-containing inflammasomes, activation of caspase-1, and subsequent processing and secretion of bioactive interleukin-1beta
  • interacting with BTG2
  • TOB1 binds CNOT8 deadenylase and recruits it to CPEB3 to form a ternary complex
  • anti-proliferative activity of BTG1, BTG2, BTG3, BTG4, TOB1, TOB2 proteins is mediated through interactions with the CNOT7, CNOT8 deadenylase enzymes
  • CNOT7, CNOT8 cooperate with CNOT6, CNOT6L in mRNA deadenylation, suggesting that the enzyme activities of CNOT7, CNOT8 and CNOT6, CNOT6L are regulated via allosteric interactions within the nuclease module
  • BTG2 bridges PABPC1 RNA-binding domains and CNOT7, CNOT8 deadenylase to control cell proliferation
  • BTG4 functions as an adaptor by recruiting the CCR4-NOT catalytic subunits CNOT7 and CNOT8, which are involved in mRNA decay
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in myelodysplastic syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS