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FLASH GENE
Symbol CNOT8 contributors: mct/npt/pgu - updated : 30-05-2008
HGNC name CCR4-NOT transcription complex, subunit 8
HGNC id 9207
Location 5q31-q33      Physical location : 154.238.197 - 154.256.351
Synonym name
  • POP2 (yeast homolog)
  • carbon catabolic repressor protein (CCR4) associative factor 1
  • cellular pyrin domain-only protein 2
  • CAF1-like protein
  • PGK promoter directed over production
  • Synonym symbol(s) CAF1, POP2, CALIF, CAF2
    DNA
    TYPE functioning gene
    STRUCTURE 18.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D5S410 - CNOT8 - D5S487 - qter
    Authors Fidler (99)
    Physical map
    GLULL1 5q33 glutamate-ammonia ligase (glutamine synthase)-like 1 NMU2R 5q33.2 neuromedin U receptor 2 GRIA1 5q33 glutamate receptor, ionotropic, AMPA 1 C5orf3 5q31-q32 chromosome 5 open reading frame 3 MFAP3 5q32 microfibrillar-associated protein 3 GALNT10 5q33.2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) FLJ11526 5q33.2 hypothetical protein FLJ11526 HAND1 5q32 heart and neural crest derivatives expressed 1 LOC389339 5 LOC389339 LARP 5q33.2 likely ortholog of mouse la related protein C5orf4 5q31-q32 chromosome 5 open reading frame 4 CNOT8 5q31-q33 CCR4-NOT transcription complex, subunit 8 GEMIN5 5q33.3 gem (nuclear organelle) associated protein 5 MRPL22 5q33.1-q33.3 mitochondrial ribosomal protein L22 LOC285643 5q33.2 similar to Chromosome-associated kinesin KIF4A (Chromokinesin) LOC391842 5 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) LOC389340 5 LOC389340 SGCD 5q33 sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) LOC153743 5q33.3 similar to protein phosphatase 1, regulatory (inhibitor) subunit 2 LOC91937 5q33.3 hypothetical protein BC008988 HAVCR1 5q33.2 hepatitis A virus cellular receptor 1 HAVCR2 5q34 hepatitis A virus cellular receptor 2 CRSP9 5q33.2 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa MGC26988 5q33.3 hypothetical protein MGC26988 ITK 5q33.1 IL2-inducible T-cell kinase CYFIP2 5q34 cytoplasmic FMR1 interacting protein 2 LOC348938 5q33.3 hypothetical protein LOC348938 ADAM19 5q32-q33 a disintegrin and metalloproteinase domain 19 (meltrin beta) SOX30 5q33 a disintegrin and metalloproteinase domain 19 (meltrin beta) LOC389341 5 similar to RIKEN cDNA 4921536K21 FLJ20546 5q33.3 hypothetical protein FLJ20546
    regionally located localized in the critical region of 5q-syndrome
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2550 33.5 292 - 2007 17178784
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three glutamine stretches
  • a proline-rich region
  • a serine/threonine rich region
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae
    Homologene
    FAMILY
  • CAF1 family
  • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • negative control of cell proliferation associated with cell-cell contact through interaction with BTG1
  • deadenylase interacting with TOB1 that is involved in the general mechanism of mRNA decay by mediating mRNA deadenylation
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CCR4-NOT (CAF1) complex involved in the control of gene expression
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with BTG1 (potential tumor suppressor), driving the formation of CAF1 complex with NOTs proteins
  • binds to PYCARD and NLRP2, thereby blocking formation of cryopyrin and NLRP2-containing inflammasomes, activation of caspase-1, and subsequent processing and secretion of bioactive interleukin-1beta
  • interacting with BTG2
  • TOB1 binds CNOT8 deadenylase and recruits it to CPEB3 to form a ternary complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in myelodysplastic syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS