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FLASH GENE
Symbol CNOT6L contributors: mct - updated : 25-10-2011
HGNC name CCR4-NOT transcription complex, subunit 6-like
HGNC id 18042
Location 4q13.3      Physical location : 78.634.541 - 78.740.544
Synonym name carbon catabolite repressor protein 4 homolog B
Synonym symbol(s) FLJ23561, FLJ25459, DKFZp434K098, CCR4B
EC.number 3.1.-.-
DNA
TYPE functioning gene
STRUCTURE 106.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ASAHL 4q21.1 N-acylsphingosine amidohydrolase (acid ceramidase)-like FLJ10498 4q21.21 hypothetical protein FLJ10498 CXCL9 4q21.2 chemokine (C-X-C motif) ligand 9 CXCL10 4q21.2 chemokine (C-X-C motif) ligand 10 CXCL11 4q21.2 chemokine (C-X-C motif) ligand 11 ART3 4p15.1-p14 ADP-ribosyltransferase 3 NUP54 4q21.1 nucleoporin 54kDa SCARB2 4q21.1 scavenger receptor class B, member 2 GENX-3414 4q24-q25 genethonin 1 FLJ25770 4q21.22 hypothetical protein FLJ25770 ShrmL 4q21.22 Shroom-related protein LOC152825 4q21.22 similar to ribosomal protein L26 LOC345079 4q21.22 similar to RIKEN cDNA 5730467H21 FLJ10849 4q21.22 hypothetical protein FLJ10849 AF357530 4q21.1 thioredoxin 1 pseudogene 3 CCNI 4pter-qter cyclin I LOC339966 4q21.22 similar to Gene product with similarity to Ubiquitin binding enzyme CCNG2 4q21.22 cyclin G2 CXCL13 4q21 chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) CNOT6L 4q13.3 CCR4-NOT transcription complex, subunit 6-like MRPL1 4q21.1 mitochondrial ribosomal protein L1 LOC391670 4 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) FRAS1 4q21.21 Fraser syndrome 1 ANXA3 4q13-q22 annexin A3 LOC391671 4 similar to ribosomal protein S21; 40S ribosomal protein S21 BMP2K 4q21.23 BMP2 inducible kinase PAQR3 4q21.23 progestin and adipoQ receptor family member III GK2 4q13 glycerol kinase 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 8794 63 555 - 2011 21233283
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal leucine-rich repeat (LRR) domain influenced its subcellular localization but was not required for its deadenylase activity
  • active site of CNOT6L should recognize the RNA substrate through its negatively charged surface
  • HOMOLOGY
    intraspecies homolog to CNOT6
    Homologene
    FAMILY
  • CCR4/nocturin family
  • CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • localized mainly in the cytoplasm and displays deadenylase activity
  • basic FUNCTION
  • negative control of cell proliferation associated with cell-cell contact through interaction with BTG1
  • regulates cell growth in a manner dependent on its deadenylase activity
  • may be involved in various cellular events that include cell proliferation
  • play a role in cell survival, in contrast to the CNOT7 and CNOT8 deadenylase subunits of CCR4-NOT complex
  • key regulator of insulin-like growth factor-binding protein 5, which mediates cell cycle arrest and senescence via a TP53-dependent pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CCR4-NOT (CAF1) complex involved in the control of gene expression
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS