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FLASH GENE
Symbol CNOT6 contributors: mct - updated : 25-10-2011
HGNC name CCR4-NOT transcription complex, subunit 6
HGNC id 14099
Location 5q35.3      Physical location : 179.921.416 - 180.005.352
Synonym name
  • homo sapiens KIAA1194 (KIAA1194), mRNA
  • yeast glucose repressible alcohol dehydrogenase transcriptional effector homolog
  • cytoplasmic deadenylase
  • carbon catabolite repressor protein 4 homolog
  • CCR4 carbon catabolite repression 4-like
  • Synonym symbol(s) KIAA1194, CCR4A
    EC.number 3.1.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 83.94 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 6178 - 557 - 2011 21233283
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal nuclease domain with homology to the endonuclease-exonuclease-phosphatase (EEP) family of enzymes
  • HOMOLOGY
    interspecies homolog to yeast glucose repressible alcohol dehydrogenase transcriptional effector
    intraspecies homolog to CNOT6L
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • potentiate nuclear receptor activity
  • plays a role in the regulation of certain endogenous RARalpha target genes and that RQCD1 and might mediate their function through their interaction with ZNF335
  • play a role in cell survival, in contrast to the CNOT7 and CNOT8 deadenylase subunits of CCR4-NOT complex
  • key regulator of insulin-like growth factor-binding protein 5, which mediates cell cycle arrest and senescence via a TP53-dependent pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targets DNA-damage response proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS