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FLASH GENE
Symbol CNOT4 contributors: mct/npt - updated : 22-05-2010
HGNC name CCR4-NOT transcription complex, subunit 4
HGNC id 7880
Location 7q33      Physical location : 135.046.546 - 135.194.875
Synonym name
  • negative regulator of transcription 4,S.cerevisiae homolog
  • CCR4-associated factor 4
  • E3 ubiquitin-protein ligase CNOT4
  • potential transcriptional repressor NOT4Hp
  • Synonym symbol(s) NOT4, NOT4H, CCR4-NOT, CLONE243
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 148.30 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FAM10A7 11p15-p14 family with sequence similarity 10, member A7 SEC8 FLJ32786 7q33 hypothetical protein FLJ32786 SLC35B4 7q33 solute carrier family 35, member B4 AKR1B1 7q25 aldo-keto reductase family 1, member B1 (aldose reductase) AKR1B10 7q33 aldo-keto reductase family 1, member B10 (aldose reductase) LOC392097 7 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta BPGM 7q32 2,3-bisphosphoglycerate mutase LOC392098 7 similar to beta-tubulin CALD1 7q33-q34 caldesmon 1 LOC340351 7q33 hypothetical protein LOC340351 LOC346671 7q33 pseudogene of RING finger protein 14 FLJ11000 7q33 hypothetical protein FLJ11000 MGC5242 7q33 hypothetical protein MGC5242 KIAA1466 7q33 KIAA1466 protein HSPC049 7q33 HSPC049 protein LOC346673 7q33 STRA8 LOC346674 7q33 similar to Na+/L-ascorbic acid transporter 1; SVCT1 CNOT4 7q33 CCR4-NOT transcription complex, subunit 4 LOC392099 7 hypothetical gene supported by AK075360; NM_003002 NUP205 7q33 nucleoporin 205kDa LOC136321 7q33 similar to 60S ribosomal protein L15 SLC13A4 7q33 solute carrier family 13 (sodium/sulfate symporters), member 4 LOC389558 7 similar to HWKM1940 MTPN 7q33-q35 myotrophin LOC392100 7 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC389559 7 LOC389559 CHRM2 7q31-q35 cholinergic receptor, muscarinic 2 LOC389560 7 LOC389560 PTN 7q33-q34 pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) DGKI 7q32.3-q33 diacylglycerol kinase, iota
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3333 70 639 - Albert (2000)
    11 - 2808 63 572 - Albert (2000)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  moderately
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • RNA recognition motif
  • N terminal domain with two putative zinc fngers of the C4C4 type (RING finger) that acts as an E3 ubiquitin ligase and specifically interacts with UBE2D2, a ubiquitin-conjugating enzyme
  • C terminal bipartite nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to C.elegans C49h3.5
    ortholog to yeast S.cerevisiae Ccr4-Not
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • functions as an E3 ligase by modulating UBE2D2-mediated stress responses (Mulder 2007)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CCR4-NOT (CAF1) complex involved in the control of gene expression
  • CNOT4 complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay (Lau 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CNOTs proteins
  • interacting with NANOS2, a deadenylation complex , which can cleave poly(A) RNA (Suzuki 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS