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FLASH GENE
Symbol CNOT4 contributors: mct/npt - updated : 22-05-2010
HGNC name CCR4-NOT transcription complex, subunit 4
HGNC id 7880
Location 7q33      Physical location : 135.046.546 - 135.194.875
Synonym name
  • negative regulator of transcription 4,S.cerevisiae homolog
  • CCR4-associated factor 4
  • E3 ubiquitin-protein ligase CNOT4
  • potential transcriptional repressor NOT4Hp
  • Synonym symbol(s) NOT4, NOT4H, CCR4-NOT, CLONE243
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 148.30 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3333 70 639 - Albert (2000)
    11 - 2808 63 572 - Albert (2000)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  moderately
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • RNA recognition motif
  • N terminal domain with two putative zinc fngers of the C4C4 type (RING finger) that acts as an E3 ubiquitin ligase and specifically interacts with UBE2D2, a ubiquitin-conjugating enzyme
  • C terminal bipartite nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to C.elegans C49h3.5
    ortholog to yeast S.cerevisiae Ccr4-Not
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • functions as an E3 ligase by modulating UBE2D2-mediated stress responses (Mulder 2007)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CCR4-NOT (CAF1) complex involved in the control of gene expression
  • CNOT4 complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay (Lau 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CNOTs proteins
  • interacting with NANOS2, a deadenylation complex , which can cleave poly(A) RNA (Suzuki 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS