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FLASH GENE

Symbol

CNOT4

contributors: mct/npt - updated : 22-05-2010

HGNC name	CCR4-NOT transcription complex, subunit 4
HGNC id	7880

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q33      Physical location : 135.046.546 - 135.194.875
Synonym name	negative regulator of transcription 4,S.cerevisiae homolog
	CCR4-associated factor 4
	E3 ubiquitin-protein ligase CNOT4
	potential transcriptional repressor NOT4Hp
Synonym symbol(s)	NOT4, NOT4H, CCR4-NOT, CLONE243
EC.number	6.3.2.-

DNA

TYPE	functioning gene
STRUCTURE	148.30 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_013316 11 - 3333 NP_037448 70 639 - Albert (2000) NM_001008225 11 - 2808 NP_001008226 63 572 - Albert (2000)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Nervous brain       highly Reproductive male system prostate     moderately Respiratory lung       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	RNA recognition motif
	N terminal domain with two putative zinc fngers of the C4C4 type (RING finger) that acts as an E3 ubiquitin ligase and specifically interacts with UBE2D2, a ubiquitin-conjugating enzyme
	C terminal bipartite nuclear localization signal (NLS)

HOMOLOGY

interspecies	homolog to C.elegans C49h3.5
	ortholog to yeast S.cerevisiae Ccr4-Not

Homologene

FAMILY

CATEGORY

enzyme , regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

functions as an E3 ligase by modulating UBE2D2-mediated stress responses (Mulder 2007)

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the CCR4-NOT (CAF1) complex involved in the control of gene expression
	CNOT4 complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay (Lau 2009)

INTERACTION

DNA

RNA

small molecule

protein	CNOTs proteins
	interacting with NANOS2, a deadenylation complex , which can cleave poly(A) RNA (Suzuki 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS