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FLASH GENE
Symbol CNOT2 contributors: mct - updated : 07-12-2015
HGNC name CCR4-NOT transcription complex, subunit 2
HGNC id 7878
Location 12q13.2      Physical location : 70.636.776 - 70.748.772
Synonym symbol(s) NOT2, CDC36, NOT2H, HSPC131
DNA
TYPE functioning gene
STRUCTURE 112.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure direct regulation of promoter activity by components of the Ccr4-Not complex (Not-Box motif)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon lowly
 mouthtongue   
Endocrinethyroid    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
Not-Box motif with repression function
HOMOLOGY
interspecies ortholog to yeast Ccr4-not
Homologene
FAMILY
CATEGORY regulatory , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • controling mRNA metabolism at multiple levels
  • CNOT1, CNOT2, and CNOT3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in Embryonic stem cell (ESC)
  • a fraction of all HIPK family members associates with the CCR4-NOT components CNOT2 and CNOT3
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the CCR4-NOT (CAF1) complex involved in the control of gene expression
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CNOTs protein
  • HIPK2 and HIPK1 restrict CNOT2-dependent mRNA decay
  • ERG is recruited to mRNAs via interaction with RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS