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FLASH GENE
Symbol CNN3 contributors: npt/mct - updated : 16-02-2015
HGNC name calponin 3, acidic
HGNC id 2157
Location 1p21.3      Physical location : 95.362.508 - 95.392.735
Synonym name
  • calponin, acidic isoform
  • h3/acidic calponin
  • Synonym symbol(s) CALPA, AcAp
    DNA
    TYPE functioning gene
    STRUCTURE 30.23 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2082 - 329 - 2007 17825283
    EXPRESSION
    Rna function mRNA expressed in cartilage tissue and isolated chondrocytes
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     liver    
    Endocrineadrenal gland   highly
    Nervousbrain    
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivecartilage  highly Homo sapiens
    Muscularsmooth   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text expressed in cytotrophoblasts in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a markedly acidic C terminus
  • one calponin homology domain
  • HOMOLOGY
    interspecies homolog to murine Cnn3
    Homologene
    FAMILY
  • calponin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in the regulation and modulation of smooth muscle contraction
  • key factor in the regulation of spine plasticity and synaptic activity
  • potential role in the regulation of BMP-dependent cellular responses
  • actin-binding protein, that potentially controls fibroblast migration by regulation of ERK1/2-mediated l-caldesmon phosphorylation
  • regulates actin cytoskeleton rearrangement which is required for the plasma membranes of trophoblasts to become fusion competent
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • importance of the MAP3K1-CNN3 signaling pathway to cell contractility
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin, calmodulin, tropomyosin binding
  • interacted with SMAD1 and SMAD5 and overexpression led to an attenuation of BMP-dependent transcription
  • MAP3K1 colocalizes with CNN3 at the actin cytoskeleton and phosphorylates it, leading to an increase in the cell-generated traction stress
  • cell & other
    REGULATION
    Other downregulated during dedifferentiation of vascular smooth muscle cell
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS