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FLASH GENE
Symbol CNN2 contributors: mct/npt - updated : 08-03-2010
HGNC name calponin 2
HGNC id 2156
Location 19p13.3      Physical location : 1.026.297 - 1.039.063
Synonym name
  • calponin H2, smooth muscle
  • neutral calponin
  • Synonym symbol(s) CALPH, CLP2
    DNA
    TYPE functioning gene
    STRUCTURE 12.77 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2478 33.6 309 - Hossain (2003)
    6 - 2361 29.4 270 - Hossain (2003)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Reproductivefemale systembreast   
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Muscularsmooth  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period growth/childhood, ageing
    Text upregulated in the stomach and bladder during postnatal development, but is decreased to low levels in quiescent smooth muscle cells (Hossain 2003)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one calponin homology domain
  • HOMOLOGY
    interspecies homolog to murine Cnn2
    intraspecies homolog to non-muscle calponin CNN3,closely
    Homologene
    FAMILY
  • calponin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • may be involved in the structural organization and/or anchorage of actin filaments and may function in the cell adhesion mechanism
  • conserved mechanism for its role in regulating actin filaments in smooth muscle and non-muscle cells (Jin 2003)
  • may regulate cytokinesis by inhibiting the activity of the actin cytoskeleton (Hossain 2003)
  • represents a novel manifestation of mechanical tension responsive gene regulation that may modify cytoskeleton function (Hossain 2005)
  • actin-binding protein implicated in cytoskeletal organization (Tang 2006)
  • plays an important role in the migration of endothelial cells both and its expression is critical for proper vascular development (Tang 2006)
  • role in regulating macrophage motility and phagocytosis (Huang 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin, calmodulin, tropomyosin binding
  • bind F-actin with similar affinity as CNN1 (Jin 2003)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS