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FLASH GENE
Symbol CNN1 contributors: mct/npt - updated : 08-03-2010
HGNC name calponin 1, basic, smooth muscle
HGNC id 2155
Location 19p13.2      Physical location : 11.649.578 - 11.661.138
Synonym name calponins, basic
Synonym symbol(s) CALPB, SMCC, CLP1, Sm-Calp, calponin H1
DNA
TYPE functioning gene
STRUCTURE 11.06 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1599 - 297 - Takahashi (1996)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselsaorta   
Digestiveesophagus   highly
 intestinesmall intestine  highly
 stomach   highly
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one calponin homology domain
  • HOMOLOGY
    interspecies homolog to murine Cnn1
    Homologene
    FAMILY
  • calponin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in the regulation and modulation of smooth muscle contraction
  • conserved mechanism for its role in regulating actin filaments in smooth muscle and non-muscle cells (Jin 2003)
  • smooth muscle-specific, actin-binding protein that is involved in the regulation of smooth muscle contractile activity (Morioka 2003)
  • with GSN are reported to play signaling roles in addition to their better-characterized actin-binding properties and it is possible that the GCC regulates both of these functions (Ferjani 2007)
  • plays an important role in the maturation of blood vessels (Yamamura 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • form a tight gelsolin: calponin complex (GCC)(Ferjani 2007)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin, calmodulin, tropomyosin binding
  • bind F-actin with similar affinity as CNN2 (Jin 2003)
  • cell & other
    REGULATION
    Other downregulated during the differentiation of vascular smooth muscle cell
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    tumoral     --low  
    in human colon cancer blood vessels (Yanagisawa 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target implications for therapeutic strategies targeting tumor vasculature for treatment of human cancers (Yamamura 2007)
    ANIMAL & CELL MODELS