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FLASH GENE
Symbol CNKSR2 contributors: - updated : 13-04-2006
HGNC name connector enhancer of kinase suppressor of Ras 2
HGNC id 19701
Location Xp22.13      Physical location : 21.392.535 - 21.672.812
Synonym name
  • membrane-associated guanylate kinase interacting protein 2/Maguin 2
  • connector enhancer of KSR2 (kinase suppressor of Ras)
    • Synonym symbol(s) KIAA0902, CNK2
    DNA
    TYPE functioning gene
    STRUCTURE 277.00 kb     22 Exon(s)
    MAPPING cloned Y linked N status
    Map pter - PHKA2 - DXS8004 - DXS3424 - DXS8005 - DXS8176 - EIF1AX - RPS6KA3 - DXS8267 - DXS8268 - DXS1229 - DXS1528 - DXS8266 - DXS8007 - DXS1390 - DXS8008 - CNKSR2 - DXS7293 - DXS8250 - DXS365 - cen
    Authors Zhang (02)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   moderately
     brainhindbraincerebellum moderately
     brainbasal nucleicaudate nucleus moderately
     braindiencephalonhypothalamus moderately
     braindiencephalonamygdala moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PH domain
  • STAR (sterile alpha motif) domain
  • PDZ domain
    • HOMOLOGY
    interspecies homolog to Drosophila kinase suppressor of RAS
    homolog to rattus Maguin 1,membrane associated GUK interacting protein
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text cell junction
    basic FUNCTION regulator of signaling
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    RAS/MAPK signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting and targeting with RAF to specific subcellular compartments upon RAS activation
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS