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FLASH GENE
Symbol CNIH2 contributors: mct - updated : 16-02-2011
HGNC name cornichon homolog 2 (Drosophila)
HGNC id 28744
Location 11q13.1      Physical location : 66.045.695 - 66.051.683
Synonym name cornichon-like protein
Synonym symbol(s) MGC50896, CNIL, CNIH-2
DNA
TYPE functioning gene
STRUCTURE 5.99 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1399 - 160 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervouspyramidal cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • cornichon family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text display a restricted distribution and are much less abundant than CACNG2
    basic FUNCTION
  • part of conserved protein family that acts in the selective transport and maturation of TGFalpha family proteins
  • acting as chaperones for other proteins
  • can affect the trafficking of AMPARS (GRIA1, GRIA2, GRIA3, and GRIN2B), they were not detected on the surface of neurons and failed to alter the kinetics of endogenous AMPARs
  • can modestly enhance the surface expression of AMPARs in neurons, in the absence of CACNG2
  • modulates neuronal AMPA receptor auxiliary subunit assembly by regulating the number of TARPs within an AMPA receptor complex to modulate receptor gating and pharmacology
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS