SUBCELLULAR LOCALIZATION
| plasma membrane
|
| intracellular
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
|
| intracellular,nuclear envelope
|
text
| sarcoplasmic reticulum |
|
localized to the costamere |
|
characterization of CMYA5 and XIRP2 revealed localization of their protein products to the muscle costamere |
|
CMYA5, FSD2 and RYR2 co-localise at the junctional sarcoplasmic reticulum of isolated cardiomyocytes |
|
striated muscle protein that co-localizes with Z-lines, junctional sarcoplasmic reticulum proteins, and transverse tubules in mature cardiomyocytes |
basic FUNCTION
| Z-disc-related protein, costameric protein functioning as a muscle-specific protein kinase A (PKA) anchoring protein or AKAP1 |
|
functions directly downstream of MEF2A at the costamere in striated muscle potentially playing a role in myofibrillogenesis |
|
having ability to anchor AKAP1 at the costamere (may have profound regulatory implications given that dystrophin has been shown to be phosphorylated by AKAP1) |
|
muscle-specific protein which function in vesicular trafficking and protein kinase A signaling and implicated in the pathogenesis of Duchenne muscular dystrophy |
|
is an A kinase anchoring protein, raising the possibility that together with desmin and other cytoskeletal and signaling proteins, it could participate in the subcellular targeting of protein kinase A activity in striated muscle |
|
novel role for the CMYA5 complex in the assembly of ryanodine receptor clusters in striated muscle |
|
is essential for both cardiac and brain structure and function and its deficiency leads to cardiomyopathy and schizophrenia-associated symptoms |
|
CMYA5 anchors junctional sarcoplasmic reticulum to Z-lines, establishes dyad architecture, and regulates dyad Ca2+ release |