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FLASH GENE
Symbol CMTM1 contributors: - updated : 12-05-2006
HGNC name CKLF-like MARVEL transmembrane domain containing 1
HGNC id 19172
Location 16q22.1      Physical location : 66.600.293 - 66.613.036
Synonym name
  • chemokine-like factor-like protein CKLFH1
  • chemokine-like factor super family 1
  • Synonym symbol(s) CKLFH1, CKLFH1a, CKLFSF1, MGC71870
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 12.00 kb     7 Exon(s)
    regulatory sequence Promoter (TATA box)
    Binding site   transcription factor
    text structure
  • a promoter region in the last intron of the upstream gene, CKLF
  • a typical TATA box (TATATAA) and multiple potential transcription factor binding sites, providing further evidence for this being a functional promoter for CMTM1
  • last intron/exon region contains a novel eukaryotic promoter capable of directing the expression of the downstream gene, CMTM2
  • MAPPING cloned Y linked N status provisional
    Map cen - TM4SF11 - CCL22 - CX3CL1 - CKLF - CMTM1 - CMTM2 - CMTM3 - CMTM4 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 784 - 169 - Han
    - splicing 680 - 94 - Wang
    - splicing 768 - 114 - Han
    - splicing 643 - 122 - Han
    - splicing 625 - 122 - Han
    - splicing 610 61 - - Han
    - splicing 764 - 92 - Han
    - splicing 902 - 91 - Han
    - splicing 472 - 65 - Han
    - splicing 943 - 38 - Han
    - splicing 770 - 45 - Han
    - splicing 584 - 32 - Han
    - splicing 510 - 28 - Han
    - splicing 780 - 179 - Han
    - splicing 764 - 124 - Han
    - - 816 - 101 - Han
    - splicing 1079 - 286 - Wang, Strausberg
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a MARVEL domain
    HOMOLOGY
    Homologene
    FAMILY chemokine-like factor family
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • may play an important role in spermatogenesis or testicular development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS