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Symbol CMPK2 contributors: mct - updated : 13-02-2008
HGNC name cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
HGNC id 27015
Location 2p25.2      Physical location : 6.988.452 - 7.005.936
Synonym name
  • UMP-CMP kinase 2
  • cytidylate kinase 2
  • mitochondrial UMP-CMP kinase
  • thymidylate kinase family LPS-inducible member
  • Synonym symbol(s) TYKi, UMP-CMPK2
    EC.number 2.7.4.14
    DNA
    TYPE functioning gene
    STRUCTURE 25.00 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3009 - 449 - Xu (2008)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal targeting signal
  • C-terminal domain containing all consensus motifs of a nucleoside monophosphate kinase
  • HOMOLOGY
    intraspecies homolog to high homology with TMPK
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity
  • first pyrimidine nucleoside monophosphate kinase that has been identified in mitochondria
  • may be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein able to phosphorylate dUMP, dCMP, CMP, and UMP with ATP as phosphate donor
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS