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FLASH GENE
Symbol CMKLR1 contributors: mct/npt/pgu - updated : 10-07-2017
HGNC name chemokine-like receptor 1
HGNC id 2121
Location 12q23.3      Physical location : 108.681.821 - 108.733.094
Synonym name
  • chemerin receptor
  • G-protein coupled receptor DEZ
  • G-protein coupled receptor ChemR23
  • orphan G-protein coupled receptor, Dez
  • resolvin E1 receptor
  • Synonym symbol(s) CHEMR23, DEZ, CML1, CHEMERINR, MGC126105, MGC126106
    DNA
    TYPE functioning gene
    STRUCTURE 47.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RPC2 12q24.11 RNA polymerase III subunit RPC2 RFX4 12q24 regulatory factor X, 4 (influences HLA class II expression) hSyn 12q24.11 brain synembryn LOC390356 12 similar to translation elongation factor eEF-1 beta chain - rabbit MGC17943 12q24.11 hypothetical protein MGC17943 LOC80298 12q24.1 transcription termination factor-like protein CRY1 12q23-q24.1 cryptochrome 1 (photolyase-like) LOC390357 12 similar to Cca3 protein BTBD11 12q24.11 BTB (POZ) domain containing 11 PWP1 12q24.11 nuclear phosphoprotein similar to S. cerevisiae PWP1 PRDM4 12q23-q24.1 PR domain containing 4 ASCL4 12q24.11 class II bHLH protein ASCL4 LOC390358 12 similar to RET finger protein-like 3 LOC390359 12 similar to programmed cell death 2 isoform 2; zinc finger protein Rp-8; programmed cell death 2/Rp8 homolog KIAA0789 12q24.11 similar to programmed cell death 2 isoform 2; zinc finger protein Rp-8; programmed cell death 2/Rp8 homolog LOC196469 12q24.11 similar to apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; phorbolin-like protein MDS019 CMKLR1 12q24.1 chemokine-like receptor 1 HYPE 12q24.1 chemokine-like receptor 1 SART3 12q24.1 squamous cell carcinoma antigen recognised by T cells 3 NIFU 12-q24.1 squamous cell carcinoma antigen recognised by T cells 3 LOC338773 12q24.12 hypothetical protein LOC338773 SELPLG 12q24 selectin P ligand CORO1C 12q24.1 coronin, actin binding protein, 1C SSH1 12q24.12 slingshot 1 DAO 12q24.12 D-amino-acid oxidase DKFZp761H039 12q24.12 hypothetical protein DKFZp761H039 USP30 12q23.3 ubiquitin specific protease 30 LOC121642 12q24.12 similar to hypothetical protein 9530023G02 UNG 12q23-q24.1 uracil-DNA glycosylase LOC387883 12 LOC387883 ACACB 12q24.1 acetyl-Coenzyme A carboxylase beta FOXN4 12q24.12 forkhead box N4 LOC387884 12 LOC387884 FLJ37587 12q24.12 hypothetical protein FLJ37587 KCTD10 12q24.12 potassium channel tetramerisation domain containing 10 UBE3B 12q24.12 potassium channel tetramerisation domain containing 10 MMAB MVK 12q24 mevalonate kinase (mevalonic aciduria) MGC14436 12q24.12 hypothetical protein MGC14436 FLJ14721 12q24.12 hypothetical protein FLJ14721 TRPV4 12q24.1 transient receptor potential cation channel, subfamily V, member 4 GLTP 12q24.12 glycolipid transfer protein MGC10854 12q24.12 hypothetical protein MGC10854 GIT2 12q24.1 G protein-coupled receptor kinase-interactor 2 ANKRD13 12q24.12 ankyrin repeat domain 13 LOC144705 12q24.12 hypothetical gene supported by AF086409
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 5283 - 373 - 1997 9425281
    3 - 5420 - 371 - 1997 9425281
    4 - 5496 - 373 - 1997 9425281
    3 - 5110 - 373 - 1997 9425281
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid    
     thyroid    
    Lymphoid/Immunespleen    
    Respiratoryrespiratory tracttrachea   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialbarrier liningepidermis   Homo sapiens
    Muscularstriatumskeletal   Mus musculusAdult
    Muscularstriatumskeletal   Mus musculusFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell
    Lymphoid/Immunemacrophage
    not specificadipocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text developing osseous and cartilaginous tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7 TM) receptor
  • HOMOLOGY
    interspecies homolog to murine Cmklr1
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • orphan receptor playing a role in bone metabolism
  • could be a chemotactic peptide receptor
  • may have a function in bone metabolism
  • acting as a coreceptor for immunodeficiency viruses that does not belong to the chemokine receptor family
  • playing a role in the mediation of the autocrine/paracrine effects of chemerin
  • serpentine receptor expressed by mononuclear phagocytes and dendritic cells
  • playing a role in the recruitment of blood NK cells and its ligand chemerin is a key factor for the colocalization of NK cells and dendritic cells subsets in pathologic peripheral tissues
  • potential critical role for CMKLR1:chemerin in shaping the nature (either proinflammatory or suppressive) in macrophage-mediated immune responses
  • involved in chemerin induced inflammatory response/chemotaxis and specific recruitment of antigen-presenting cells to inflammatory sites
  • regulates skeletal muscle cell myogenesis
  • roles for RARRES2/CMKLR1-mediated in dental epithelial-dental mesenchymal (DE-DM) signaling during tooth morphogenesis
  • G protein-coupled receptor found on select immune, epithelial, and dorsal root ganglion/spinal cord neuronal cells
  • role of CMKLR1 in the attraction of macrophages to inflamed tissue by RARRES2 and in the initiation of resolution of inflammation through resolvin E1-mediated repolarization of human M1 macrophages toward resolution-type macrophages
  • is a novel WNT responsive gene that functions in a negative feedback loop to limit osteoblastogenic WNT signaling
  • CMKLR1 exacerbated the proliferation and migration of vascular smooth muscle cells (VSMCs) by activating MAPK3/MAPK1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component RARRES2/CMKLR1 system has been implicated in mediating cellular migration under inflammatory condition
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding chemerin (RARRES2) on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis
  • also serves as a receptor for resolvins and lipoxins
  • plasma protein-derived chemoattractant chemerin is a ligand for CMKLR1 and activation of CMKLR1 with chemerin induces the migration of macrophages and dendritic cells, suggesting a proinflammatory role
  • CCRL2 binds chemerin and increases local chemerin concentration to efficiently present it to CMKLR1 on nearby cells, providing a link between CCRL2 and CMKLR1
  • proteolytic activation of CMKLR1 by KLK7 breaks an ionic linkage and results in C-terminal rearrangement
  • is a new addition to the repertoire of cell surface molecules that are responsible for APP processing and clearance
  • cell & other
    REGULATION
    activated by both lipid and peptide agonists, resolvin E1 and RARRES2, respectively
    Other tightly regulated in response to inflammatory and anti-inflammatory stimuli
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in psoriasis and atopic dermatitis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mesenchymal stem cell (MSC) from Cmklr1 knockout (-/-) mice exhibited similar dependency on Notch signaling to maintain osteoblastogenic differentiation
  • Cmklr1 null mice have a subtle skeletal muscle deficit beginning from embryonic life that persists during postnatal life