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FLASH GENE
Symbol CMKLR1 contributors: mct/npt/pgu - updated : 10-07-2017
HGNC name chemokine-like receptor 1
HGNC id 2121
Location 12q23.3      Physical location : 108.681.821 - 108.733.094
Synonym name
  • chemerin receptor
  • G-protein coupled receptor DEZ
  • G-protein coupled receptor ChemR23
  • orphan G-protein coupled receptor, Dez
  • resolvin E1 receptor
  • Synonym symbol(s) CHEMR23, DEZ, CML1, CHEMERINR, MGC126105, MGC126106
    DNA
    TYPE functioning gene
    STRUCTURE 47.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 5283 - 373 - 1997 9425281
    3 - 5420 - 371 - 1997 9425281
    4 - 5496 - 373 - 1997 9425281
    3 - 5110 - 373 - 1997 9425281
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid    
     thyroid    
    Lymphoid/Immunespleen    
    Respiratoryrespiratory tracttrachea   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialbarrier liningepidermis   Homo sapiens
    Muscularstriatumskeletal   Mus musculusAdult
    Muscularstriatumskeletal   Mus musculusFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell
    Lymphoid/Immunemacrophage
    not specificadipocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text developing osseous and cartilaginous tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7 TM) receptor
  • HOMOLOGY
    interspecies homolog to murine Cmklr1
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • orphan receptor playing a role in bone metabolism
  • could be a chemotactic peptide receptor
  • may have a function in bone metabolism
  • acting as a coreceptor for immunodeficiency viruses that does not belong to the chemokine receptor family
  • playing a role in the mediation of the autocrine/paracrine effects of chemerin
  • serpentine receptor expressed by mononuclear phagocytes and dendritic cells
  • playing a role in the recruitment of blood NK cells and its ligand chemerin is a key factor for the colocalization of NK cells and dendritic cells subsets in pathologic peripheral tissues
  • potential critical role for CMKLR1:chemerin in shaping the nature (either proinflammatory or suppressive) in macrophage-mediated immune responses
  • involved in chemerin induced inflammatory response/chemotaxis and specific recruitment of antigen-presenting cells to inflammatory sites
  • regulates skeletal muscle cell myogenesis
  • roles for RARRES2/CMKLR1-mediated in dental epithelial-dental mesenchymal (DE-DM) signaling during tooth morphogenesis
  • G protein-coupled receptor found on select immune, epithelial, and dorsal root ganglion/spinal cord neuronal cells
  • role of CMKLR1 in the attraction of macrophages to inflamed tissue by RARRES2 and in the initiation of resolution of inflammation through resolvin E1-mediated repolarization of human M1 macrophages toward resolution-type macrophages
  • is a novel WNT responsive gene that functions in a negative feedback loop to limit osteoblastogenic WNT signaling
  • CMKLR1 exacerbated the proliferation and migration of vascular smooth muscle cells (VSMCs) by activating MAPK3/MAPK1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component RARRES2/CMKLR1 system has been implicated in mediating cellular migration under inflammatory condition
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding chemerin (RARRES2) on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis
  • also serves as a receptor for resolvins and lipoxins
  • plasma protein-derived chemoattractant chemerin is a ligand for CMKLR1 and activation of CMKLR1 with chemerin induces the migration of macrophages and dendritic cells, suggesting a proinflammatory role
  • CCRL2 binds chemerin and increases local chemerin concentration to efficiently present it to CMKLR1 on nearby cells, providing a link between CCRL2 and CMKLR1
  • proteolytic activation of CMKLR1 by KLK7 breaks an ionic linkage and results in C-terminal rearrangement
  • is a new addition to the repertoire of cell surface molecules that are responsible for APP processing and clearance
  • cell & other
    REGULATION
    activated by both lipid and peptide agonists, resolvin E1 and RARRES2, respectively
    Other tightly regulated in response to inflammatory and anti-inflammatory stimuli
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in psoriasis and atopic dermatitis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mesenchymal stem cell (MSC) from Cmklr1 knockout (-/-) mice exhibited similar dependency on Notch signaling to maintain osteoblastogenic differentiation
  • Cmklr1 null mice have a subtle skeletal muscle deficit beginning from embryonic life that persists during postnatal life