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FLASH GENE
Symbol CMIP contributors: mct - updated : 24-03-2011
HGNC name c-Maf inducing protein
HGNC id 24319
Location 16q23.2      Physical location : 81.478.774 - 81.745.365
Synonym symbol(s) KIAA1694
DNA
TYPE functioning gene
STRUCTURE 266.59 kb     21 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 4359 - 773 fetal liver, kidney, peropheral mononuclear cells 2009 19019440
c-MIP
21 - 4133 - 679 fetal liver, thymus, T cells, helper 2009 19019440
Tc-MIP
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinner    Homo sapiens
Nervousbraindiencephalonamygdala highly
 brainbasal nuclei   
Reproductivefemale systemovary  highly
Respiratorylung   highly
Urinarykidney   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymhoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology domain (PH)
  • a leucine-rich repeat (LRR)-domain
  • HOMOLOGY
    interspecies homolog to chicken cmip
    Homologene
    FAMILY
    CATEGORY adaptor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • adapter protein involved in c-maf-dependent Th2 signaling pathway
  • acts downstream signaling of classical NF-kappaB pathway and may represent one of the missing links in the control of NF-kappaB activity
  • CMIP and ATP2C2 act to modulate phonological short-term memory primarily in the context of language impairment
  • key component in the molecular pathogenesis of acquired podocyte diseases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inducing c-MAF
  • partner of FLNA
  • interacts with the PIK3R1, PIK3R2 and inactivates LCK, which results in Erk1/2 and MAPK14 activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the podocytes of patients with various acquired idiopathic nephrotic syndromes in which the podocyte is the main target of injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a useful marker of nephrotic syndrome in classical Hodgkin lymphoma and its induction reflects the dysregulation of proximal signaling
  • Therapy target
    ANIMAL & CELL MODELS