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FLASH GENE
Symbol CLTA contributors: mct - updated : 31-05-2014
HGNC name clathrin, light polypeptide (Lca)
HGNC id 2090
Location 9p13.3      Physical location : 36.190.852 - 36.212.058
Synonym name clathrin light chain LCA
Synonym symbol(s) LCA
DNA
TYPE functioning gene
STRUCTURE 21.21 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
RUSC2 9p13.2 RUN and SH3 domain containing 2 LOC138729 9p13.2 hypothetical gene LOC138729 TESK1 9p13 testis-specific kinase 1 CD72 9p13.1 CD72 antigen SIT 9p13-p12 CD72 antigen MGC31967 9p13.2 hypothetical protein MGC31967 FLJ14642 9p13.2 hypothetical protein FLJ14642 CA9 9p13-p12 carbonic anhydrase IX TPM2 9p13.2-p13.1 tropomyosin 2 (beta) TLN1 9p13 talin 1 CREB3 9p13.2 cAMP responsive element binding protein 3 (luman) GBA2 9p13.3-p11.2 glucosidase, beta (bile acid) 2 KIAA0258 9pter-p22.1 KIAA0258 protein NPR2 9p21-p12 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) SPAG8 9p13-p12 sperm associated antigen 8 HINT2 9p11.2 histidine triad nucleotide binding protein 2 LOC392307 9 similar to RIKEN cDNA 4930412F15 gene NGX6 9p13.1 nasopharyngeal carcinoma related protein LOC389718 9 LOC389718 LOC392308 9 similar to Olfactory receptor 70 LOC392309 9 similar to Olfactory receptor 13J1 LOC392310 9 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) OR2S2 9p13.3-p13.1 olfactory receptor, family 2, subfamily S, member 2 LOC389719 9 hypothetical gene supported by M24070; NM_004559 LOC392311 9 similar to seven transmembrane helix receptor OR13C7P 9 olfactory receptor, family 13, subfamily C, member 7 pseudogene LOC392313 9 similar to olfactory receptor RECK 9p13-p12 reversion-inducing-cysteine-rich protein with kazal motifs C9orf19 9p12-p13 chromosome 9 open reading frame 19 CCIN 9p13-p12 calicin CLTA 9p13-p12 clathrin, light polypeptide (Lca) GNE 9p13-p12 clathrin, light polypeptide (Lca) LOC392314 9 similar to high mobility group protein homolog HMG4 RNF38 9p13-p12 ring finger protein 38 MRPS21P4 9p13.1 mitochondrial ribosomal protein S21 pseudogene 4 MELK 9p11.2 maternal embryonic leucine zipper kinase
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 splicing 1246 - 248 - 2010 21152103
LCA-B
5 splicing 1156 - 218 non brain transcript 2010 21152103
LCA-Nb
6 - 1210 - 236 - 2010 21152103
6 - 1192 - 230 - 2010 21152103
5 - 1151 - 168 - 2010 21152103
3 - 1000 - 166 - 2010 21152103
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivemale systemprostate    Homo sapiens
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
not specificstromal cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY clathrin light chain family
CATEGORY regulatory , structural protein
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic,vesicle
text
  • translocated to plasma membrane through AP2 binding
  • synaptic vesicles
  • basic FUNCTION
  • regulatory element in clathrin function
  • major protein of the polyhedral coat of coated pits and vesicles
  • contributing to regulation of coated vesicle formation to sort proteins during receptor-mediated endocytosis and organelle biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component clathrin coats formed from molecules containing 3 heavy chains and 3 light chains
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • function in intracellular membrane trafficking by acting as recruitment proteins for HIP1R, enabling HIP1R to regulate actin assembly on clathrin-coated structures
  • MAD2L2 interacts with CLTA during the G2/M phase of the cell cycle and depletion of MAD2l2 leads to a marked increase in the percentage of misaligned chromosomes and a redistribution of CLTA during mitosis
  • noradrenaline induces binding of CLTA to ADRA1B in the human prostate
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS