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FLASH GENE
Symbol CLSTN3 contributors: - updated : 24-08-2007
HGNC name calsyntenin 3
HGNC id 18371
Location 12p13.31      Physical location : 7.282.966 - 7.311.528
Synonym name alcadein beta
Synonym symbol(s) CSTN3, KIAA0726
DNA
TYPE functioning gene
STRUCTURE 27.00 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
 nerve   highly
Reproductivemale systemprostate  moderately
 male systemtestis  highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cytoplasmic synaptic Ca2+ binding domain
  • two cadherin domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Cstn3
    ortholog to murine Clstn3
    homolog to Drosophila calsyntenin-1
    homolog to C.elegans B0034.3a
    Homologene
    FAMILY
    CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION modulating calcium-mediated postsynaptic signals
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein interacting with APP (coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS