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FLASH GENE
Symbol CLSTN1 contributors: mct - updated : 28-01-2015
HGNC name calsyntenin 1
HGNC id 17447
Location 1p36.22      Physical location : 9.789.079 - 9.884.550
Synonym name
  • alcadein alpha 1
  • non-classical cadherin XB31alpha1
  • cadherin-related family member 12
  • alzheimer-related cadherin-like protein
  • Synonym symbol(s) CSTN1, KIAA0911, CST1, FLJ32258, PIK3CD, XB31alpha, alcalpha1, alcalpha2
    DNA
    TYPE functioning gene
    STRUCTURE 95.47 kb     18 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390993 1 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) DNB5 1p36.2-p36.1 deleted in neuroblastoma 5 RERE 1p36.1-p36.2 arginine-glutamic acid dipeptide (RE) repeats DKFZp566H0824 1p36.22 hypothetical protein DKFZp566H0824 LOC390994 1 similar to 60S ribosomal protein L23a ENO1 1p36.2 enolase 1, (alpha) LOC148915 1p36.22 hypothetical LOC148915 CA6 1p36.2 carbonic anhydrase VI LOC390995 1 similar to Solute carrier family 2, facilitated glucose transporter, member 5 (Glucose transporter type 5, small intestine) (Fructose transporter) SLC2A5 1p36.2 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 GPR157 1p36.22 G protein-coupled receptor 157 H6PD 1p36.3 hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) SSB1 1p36.22 SPRY domain-containing SOCS box protein SSB-1 MGC4399 1p36.22 mitochondrial carrier protein LOC199953 1p36.22 similar to expressed sequence AV028368 PIK3CD 1p36.2 phosphoinositide-3-kinase, catalytic, delta polypeptide CLSTN1 1p36.22 calsyntenin 1 CTNNBIP1 1pter-p36.31 catenin, beta interacting protein 1 LZIC 1p36.22 leucine zipper and CTNNBIP1 domain containing NMNAT1 1p36.2 nicotinamide nucleotide adenylyltransferase 1 CRBPIV 1p36.22 retinoid binding protein 7 UBE4B 1p36.3- ubiquitination factor E4B (UFD2 homolog, yeast) KIF1B 1p36.2 kinesin family member 1B LOC388593 1 LOC388593 PGD 1p36.31 phosphogluconate dehydrogenase CORT 1p36.3-p36.2 cortistatin DFFA 1p36.3-p36.2 DNA fragmentation factor, 45kDa, alpha polypeptide PEX14 1p36.3-p36.2 peroxisomal biogenesis factor 14 LOC163301 1p36.22 similar to BC035954 protein FLJ20321 1p36.22 hypothetical protein FLJ20321 FLJ37118 1p36.22 hypothetical protein FLJ37118 LOC390996 1 similar to Cofilin, non-muscle isoform TARDBP 1p36.22 TAR DNA binding protein AF311304 1p36.22 hypothetical protein AF311304 MASP2 1p36.3-p36.2 mannan-binding lectin serine protease 2 SRM 1p36-p22 spermidine synthase PMSCL2 1p36.22 polymyositis/scleroderma autoantigen 2, 100kDa FRAP1 1p36.3-p36.2 FK506 binding protein 12-rapamycin associated protein 1 CDT6 1p36.3-p36.2 angiopoietin-like factor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 5209 - 981 - 2006 16760430
    18 - 5179 - 971 - 2006 16760430
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Endocrinepancreas   highly Homo sapiens
     parathyroid   highly
    Nervousnerve   highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain moderately
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cytoplasmic synaptic Ca2+ binding domain
  • two cadherin domains
  • two highly conserved segments in the cytoplasmic domain of calsyntenin-1 mediate binding to the tetratricopeptide repeats of KLC1
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Clstn1
    homolog to Drosophila calsyntenin-1
    homolog to C.elegans B0034.3a
    Homologene
    FAMILY
    CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text type I membrane protein
    basic FUNCTION
  • modulating calcium-mediated postsynaptic signals
  • inducing vesicle association of kinesin-1 motor components and activates axonal transport
  • cargo regulating kinesin-1 function and associated with APP transport and metabolism
  • function outside the nervous system and potentially is modulator of endocrine function
  • acts as a general mediator of anterograde axonal transportation of endosomal vesicles
  • may actively contribute to axonal growth and pathfinding in the developing as well as to the maintenance of neuronal polarity in the adult nervous system
  • CLSTN1/APP organelles as carriers for sheltered anterograde axonal transport of APP
  • key role for CLSTN1 in the transport of NMDA receptors to synaptic targets, which is necessary for the maturation of neuronal circuits during early development
  • essential regulator of axon branching and neuronal compartmentalization
  • regulates transport of RAB5-containing endosomes from the cell body to specific locations of developing axons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+
    protein
  • direct interaction with the light chain of Kinesin-1 (KLC1), linking a certain type of vesicular and tubulovesicular organelles to the Kinesin-1 motor
  • interacting with APP (coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation)
  • phosphorylation of KLC1ser460 represents a mechanism for selectively regulating the binding and trafficking of CLSTN1
  • is a ligand for kinesin-1 light chains (KLC1) and APP is transported through axons on kinesin-1 molecular motors
  • disruption of CLSTN1-associated axonal transport of APP is a pathogenic mechanism in Alzheimer disease
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Alzheimer disease brains and the extent of this reduction correlates with increased APP levels
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS