| basic FUNCTION
| playing a role in the hair cells and photoreceptor synaptic functions |
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possible role in the regulation and homeostasis of actin filaments (Tian 2009) |
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forms membranous cholesterol-rich compartments on plasma membranes and interacts with and regulates the machinery involved in actin filament organization (Tian 2009) |
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may play a vital role in creating and assembling membrane microdomains involved in adhesion strengthening and signaling (Geng 2009) |
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plays a novel role in hair cell development and function (may be having necessary role for normal sensory transduction, hair cell to afferent communication and/or primary afferent neural activation) (Geng 2009) |
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CDH23, PCDH15 and ADGRV1 have been implicated in the development of cochlear hair cell stereocilia, while CLRN1 has been suggested to also play a role in synaptogenesis  |
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is likely functionally important for mechanotransduction channel activity and for proper localization of synaptic components, establishing a critical role for CLRN1 at the apical and basal poles of hair cells |
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hair cell expression of CLRN1 is likely essential for postnatal preservation of hair cell structure and hearing |
