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FLASH GENE
Symbol CLPTM1L contributors: mct - updated : 03-01-2011
HGNC name CLPTM1-like
HGNC id 24308
Location 5p15.33      Physical location : 1.318.006 - 1.345.002
Synonym name
  • cisplatin resistance related protein CRR9p
  • cisplatin resistance-related protein 9
  • cleft lip and palate transmembrane protein 1-like protein 2
  • Synonym symbol(s) CRR9, DKFZp666M1010, DKFZp761M2324, FLJ14400, FLJ32533, CRR9p
    DNA
    TYPE functioning gene
    STRUCTURE 27.00 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - D5S2774 - D5S2254E - CLPTM1L - D5S1652E - D5S678 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2164 - 538 - 2002 11850805
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • transmembrane-like domains
  • well conserved on C terminus CLPTM1
  • HOMOLOGY
    Homologene
    FAMILY
  • CLPTM1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • associated with the cisplastin-induced apoptosis
  • may be inducing apoptosis of lung cells under genotoxic exposures such as tobacco carcinogen–related stress
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in CDDP (cisplatin)-resistant ovarian tumor cell lines
    tumoral   amplification    
    in early stages of non-small cell lung cancer
    Susceptibility
  • to lung cancer
  • to squamous cell carcinoma of the head and neck
  • to skin cancer
  • Variant & Polymorphism insertion/deletion
  • SNPs of TERT-rs2736098 (C > T) and CLPTM1L-rs401681(C > T), may be associated with a reduced risk of squamous cell carcinoma of the head and neck, particularly for their combined effect )
  • SNP (rs401681) in the TERT-CLPTM1L locus identified as a susceptibility locus to skin cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS