basic FUNCTION
| dual specificity protein kinase involved in cell cycle progression, apoptosis, and telomere length regulation |
|
stabilizes CHEK1 |
|
is required for activity of ATR, stimulating its autophosphorylation and contributes to ATR checkpoint signalling (Danielsen 2009) |
|
is an insulin-regulated suppressor of hepatic gluconeogenesis and glucose output |
|
CLK2 suppresses fatty acid oxidation and ketone body production during diet-induced obesity |
|
importance of CLK2 in the regulation of fatty acid metabolism |
|
RNA splicing that ultimately controls multiple physiological processes |
|
in the hypothalamus is necessary to maintain energy homeostasis |
|
is a regulatory component of diet-induced thermogenesis in brown adipose tissue (BAT) through increased CREB-dependent expression of UCP1 |