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FLASH GENE
Symbol CLINT1 contributors: mct/npt/pgu - updated : 06-07-2010
HGNC name clathrin interactor 1
HGNC id 23186
Location 5q33.3      Physical location : 157.213.296 - 157.286.168
Synonym name
  • epsin 4
  • enthoprotin
  • epsin-related protein
  • clathrin interacting protein localized in the trans-Golgi region
  • Synonym symbol(s) KIAA0171, EPN4, EPNR, EPSINR, CLINT, ENTH, SCZD1
    DNA
    TYPE functioning gene
    STRUCTURE 72.87 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3425 68 625 - 2002 12429846
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • epsin N-terminal homology (ENTH) domain
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae hypothetical protein L8167
    Homologene
    FAMILY
  • epsin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text localizes predominantly to the Golgi region of epithelial cells as well as to more peripheral vesicular structures
    basic FUNCTION
  • clathrin-associated protein, stimulating clathrin assembly
  • playing a role in clathrin-mediated budding on internal membranes
  • playing a role in transport and stability of neurotransmitter vesicles at the synapses and within neurons
  • involved in endocytosis
  • might participate in the formation of clathrin-coated vesicles at the level of the trans-Golgi network and remains associated with the vesicles longer than clathrin and adaptors
  • with ANTH domain proteins are involved in budding of clathrin-coated vesicles
  • ENTH domain protein which are cargo adaptors for multiple SNARE proteins at the transgolgi network endosome
  • having function in epidermal development and inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to AP1, clathrin heavy chain and Arf-binding protein 2
  • binds to VTI1B, suggesting that it may be a VTI1B-selective adaptor
  • interact with SNAREs of the VTI1 family (VTI1B)
  • interactions between CLINT1 and the mammalian late endosomal SNAREs syntaxin 7 and syntaxin 8
  • binds SNARE proteins and functions in vesicle trafficking
  • adaptor for the late endosomal SNARE VTI1B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia (SCZD1)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS