SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,organelle,mitochondria,inner
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytoskeleton
|
text
| localized at the base of stereocilia and required for normal hearing |
|
CLIC4 is enriched in the outer mitochondrial membrane, whereas CLIC5 is present in the inner mitochondrial membrane |
basic FUNCTION
| involved in chloride ion transport within various subcellular compartments |
|
may play an important role in the assembly or maintenance of F-actin-based structures at the cell cortex |
|
actin-regulated membrane protein that could modify solute transport at key stages during cellular events such as apoptosis, cell and organelle division and fusion, cell-volume regulation, and cell movement |
|
associates with radixin in hair cell stereocilia and may help form or stabilize connections between the plasma membrane and the filamentous actin core |
|
is essential for normal inner ear function |
|
is localized to the cardiac mitochondria and directly modulates mitochondrial function |
|
CLIC5, is the first mitochondrial chloride channel to be identified on the molecular level in the inner mitochondrial membrane |