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FLASH GENE
Symbol CLEC9A contributors: KTN/npt - updated : 26/11/2008
HGNC name C-type lectin domain family 9, member A
HGNC id 26705
Location 12p13.2      Physical location : 10.183.275 - 10.218.564
Synonym symbol(s) UNQ9341, HEEE9341, DNGR1
DNA
TYPE functioning gene
STRUCTURE 35.29 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1673 27.2 241 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   predominantly
 thymus   predominantly
Nervousbrain   predominantly
Reproductivefemale systemplacenta  highly
 male systemtestis  moderately
cell lineage myeloid lineage cells
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-type lectin (CTLD) domain
  • a stalk region
  • a transmembrane domain
  • a cytoplasmic tail with an immunoreceptor tyrosine-based activation motif (ITAM)
  • conjugated GlycoP
    mono polymer dimer
    HOMOLOGY
    interspecies homolog to dog CLEC9A (71.7 pc)
    homolog to chimpanzee CLEC9A (98.8 pc)
    homolog to cow CLEC9A (71.3 pc)
    homolog to rattus Clec9a (60.2 pc)
    homolog to murine Clec9a (60.1 pc)
    Homologene
    FAMILY
  • C-type lectin family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type II membrane protein
    basic FUNCTION
  • functioning as an activation receptor
  • can mediate endocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • binding to sugar
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS