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FLASH GENE
Symbol CLEC5A contributors: mct - updated : 11-10-2011
HGNC name C-type lectin domain family 5, member A
HGNC id 2054
Location 7q34      Physical location : 141.627.156 - 141.646.783
Synonym name
  • myeloid DAP12 associated lectin 1
  • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5
  • Synonym symbol(s) MDL1, MGC138304, CLECSF5, MDL-1
    DNA
    TYPE functioning gene
    STRUCTURE 19.63 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3524 21.5 188 - 2011 21094529
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C-type lectin domain
  • lectin-like fold similar to the natural-killer T-cell C-type lectin domains and associates with a 12-kDa DNAX-activating protein (DAP12)4 on myeloid cells
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Clecsf5
    Homologene
    FAMILY
  • C type lectin superfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II transmembrane protein
    basic FUNCTION
  • involved in activation of myeloid cells in a calcium-dependent manner
  • ABC-transporter involved in peptide export from the matrix space, having minor effects on nuclear gene expression
  • important pattern recognition receptor in the context of dengue virus infection
  • acting as a signaling receptor for proinflammatory cytokine release
  • CLEC5A associates with both TYROBP and HCST in osteoclasts and bone marrow-derived macrophages, where HCST association depends almost entirely on TYROBP
  • key regulator of synovial injury and bone erosion during autoimmune joint inflammation
  • cell surface receptor strongly associated with the activation and differentiation of myeloid cells
  • associates with its adaptor protein TYROBP to activate a signaling cascade resulting in activation of downstream kinases in inflammatory responses
  • critical macrophage receptor for dengue virus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling signal transduction
    CLECSF5/DAP12 pathway
    a component homodimeric at the cell surface and binds to dengue virus serotypes 1-4
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with TYROBP
  • interacts with dnax-activation protein 12
  • cell & other
  • interacts with the dengue virion
  • REGULATION
    Other down-regulated when monocytes differentiate into dendritic cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    mRNA expression was significantly lower in primary acute myeloid leukemia (AML) patient samples than in macrophages and granulocytes from healthy donors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunearticular
    may be a therapeutic target for treatment of immune-mediated skeletal disorders
    ANIMAL & CELL MODELS