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FLASH GENE
Symbol CLEC4M contributors: mct/npt - updated : 28-02-2009
HGNC name C-type lectin domain family 4, member M
HGNC id 13523
Location 19p13.2      Physical location : 7.828.034 - 7.834.490
Synonym name
  • liver specific ICAM3 grabbing non integrin
  • CD209 antigen-like
  • DC-SIGN-related protein
  • dendritic cell-specific ICAM-3-grabbing non-integrin 2
  • liver/lymph node-specific ICAM-3 grabbing non-integrin
  • Synonym symbol(s) LSIGN, DCSIGNR, CD209L, CD299, DC-SIGN2, CD209L1, DCSIGNR, HP10347, LSIGN, MGC129964, MGC47866, CD209b, SIGNR1
    DNA
    TYPE functioning gene
    STRUCTURE 6.41 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - D19S5684E - D19S905 - CLEC4M - D19S848 - D19S912 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1799 39.35 348 - Feinberg (2005)
    - - 1904 42.46 375 - Feinberg (2005)
    - - 1568 30 263 - Feinberg (2005)
    - - 1775 37.82 332 - Feinberg (2005)
    - - 1587 26.15 232 - Feinberg (2005)
    - - 1838 40 353 - Feinberg (2005)
    - - 1907 42.6 376 - Feinberg (2005)
    - - 1779 33.4 296 - Feinberg (2005)
    7 - 1976 45.22 399 - Feinberg (2005)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivelivervesselsinusoid  
    Endocrineadrenal gland    
    Reproductivefemale systemplacenta   
     male systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, endometrium
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal cytoplasmic tail homolog to CDC209 (with a dileucin motif) 22 AA transmembrane domain
  • N linked glycosylation site
  • a neck with seven repeats of 23 AA sequence and carbohydrate recognition domain, tandem repeat domain, mediating oligermerization
  • a C-type lectin family domain
  • an extra-cellular domain consisting of an extended neck region encoded by tandem repeats that support the carbohydrate-recognition domain, which plays a crucial role in influencing the pathogen-binding properties of this receptor (Khoo 2008)
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface receptor binding to oligosaccharide ligands found on human tissues as well as on pathogens including viruses, bacteria, and parasites (Feinberg 2005)
  • probable pathogen-recognition receptor involved in peripheral immune surveillance in liver
  • mediating the endocytosis of pathogens which are subsequently degraded in lysosomal compartments
  • recognize a plethora of pathogens, including bacteria, viruses, and parasites
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SARS-CoV (coronavirus) binding receptor (receptor for the severe acute respiratory syndrome (SARS) virus) (Li 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to SARS-CoV (coronavirus) infection
    Variant & Polymorphism repeat homozygosity for tandem repeats plays a protective role during SARS infection, homozygosity for VNTR in exon 4 were protected against SARS coronavirus infection (protective effect was due to formation of a homotetramer, with apparently higher affinity for viral ligands, in homozygous subjects)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Clec4m helps to condition dendritic cells (DCs) in the gastrointestinal lamina propria (LPDCs) for the induction of oral tolerance in a model of food-induced anaphylaxis