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FLASH GENE
Symbol CLEC4G contributors: mct - updated : 29-06-2015
HGNC name C-type lectin superfamily 4, member G
HGNC id 24591
Location 19p13.2      Physical location : 7.793.843 - 7.797.057
Synonym name
  • liver and lymph node sinusoidal endothelial cell C-type lectin
    • Synonym symbol(s) UNQ431, DTTR431, LSECtin, LP2698
    DNA
    TYPE functioning gene
    STRUCTURE 3.21 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1377 - 293 - 2010 20127679
    9 - 1341 - 281 - 2010 20127679
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Lymphoid/Immunelymph node     Homo sapiens
     thymus     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Digestiveepithelial cell Homo sapiens
    Lymphoid/Immunedendritic cell Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • type II antifreeze protein signature
  • a single C-type lectin-like domain at the COOH terminus
    • HOMOLOGY
    interspecies homolog to murine Clec4g
    Homologene
    FAMILY C-type lectin DC-SIGN family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type II integral to membrane
    • basic FUNCTION
  • acting as a lectin receptor
  • pathogen-associated molecular pattern receptor in human myeloid cells
  • likely participates in antigen uptake and internalization, and might be a suitable target molecule in vaccination strategies
  • acts as a pathogen attachment factor for Ebolavirus and the SARS coronavirus, and its expression can be induced by interleukin-4 on monocytes and macrophages
  • specifically recognized activated T cells and negatively regulated their immune responses
  • negatively regulates hepatic T-cell immune response
  • not only acts as an attachment factor for pathogens, but also recognizes "endogenous" activated T cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • sugar
    • protein
  • CD44 is the first identified endogenous ligand of CLEC4G, and similarly, that CLEC4G is a novel ligand of CD44
  • CLEC4G-mediated signaling up-regulates the threshold of CD4(+) T cell activation via tuning the expression of CBLB
  • novel role of CLEC4G in negatively regulating BACE1 function
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    may be a promising new target for intervention in metastasis formation
    ANIMAL & CELL MODELS