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FLASH GENE
Symbol CLEC3B contributors: - updated : 27-04-2006
HGNC name C-type lectin domain family 3, member B
HGNC id 11891
Location 3p21.3      Physical location : 45.067.758 - 45.077.562
Synonym name
  • tetranectin (plasminogen binding protein)
  • plasminogen kringle 4-binding protein
    • Synonym symbol(s) TNA, TN, DKFZp686H17246
    DNA
    TYPE functioning gene
    STRUCTURE 9.00 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - VIPR1 - D3S3112 - CLEC3B - D3S2978 - cen
    Authors Durkin (97)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeanterior segmentcornea  
    cell lineage
    cell lines
    fluid/secretion serum
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal alpha helical domain required for homo trimerization
  • six cysteine residues
  • a C terminal globular carbohydrate recognition domain, binding the kringle-4 domain of plasminogen
    • HOMOLOGY
    intraspecies homolog to asialoglycoprotein receptors and cartilage core protein
    Homologene
    FAMILY C-type lectin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • plasminogen binding protein
  • muscle regeneration and muscle cell differentiation in vitro
  • involved in the mineralization phase of osteogenesis and in myogenesis during embryonic development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    prognostic marker of cancers (breast, ovarian,? others)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS