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FLASH GENE

Symbol

CLEC2A

contributors: mct/npt - updated : 29-03-2010

HGNC name	C-type lectin domain family 2, member A
HGNC id	24191

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p13.31      Physical location : 10.065.825 - 10.084.980
Synonym name	proliferation-induced lymphocyte-associated receptor
	INPE5792
	keratinocyte-associated C-type lectin
Synonym symbol(s)	UNQ5792, INPE5792, PILAR, KACL

DNA

TYPE	functioning gene
SPECIAL FEATURE	tail to tail
text	positioned just approximately 3 kb centromeric from the KLRF2 gene in a tail-to-tail orientation (Spreu 2010)
STRUCTURE	19.15 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	alternative splicing of exon 2 and of two distinct terminal exons (exon 5A/B), respectively, gives rise to four CLEC2A variants differing in the usage of the transmembrane domain and/or in the C-terminal portion of the CTL domain (Spreu 2007)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001130711 5 - 916 - 174 - Huarte (2008) variant 2 - - - isoform 2 - - - Spreu (2007) also called CLEC2A1 variant readily expressed at the cell surface, where it may serve as a ligand for NKC-encoded NK receptors

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skin/Tegument skin

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage	primarily in myeloid cell lineages, but not in epithelial cell lineages
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C-type lectin (CTL) or carbohydrate-recognition domain, most similar to the CTLD of LLT1 (Spreu 2007)

HOMOLOGY

Homologene

FAMILY

C-type lectin domain family 2

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

basic FUNCTION	induces apoptotic death on naive and early activated T cells if CD161 engagement is blocked (Huarte 2008)
	potential role in the pathogenesis of joint inflammation (Huarte 2008)
	non–disulfide-linked homodimeric surface receptor that stimulates cytotoxicity (Spreu 2010)
	plays a central role in modulating the extent of T-cell expansion (Huarte 2008)
	non-disulfide-linked homodimeric surface receptor, unique NKC-encoded receptor-ligand system that may fulfill a dedicated function in the immunobiology of human skin (Spreu 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interaction of C-type lectin-like receptors KLRF2 and CLEC2A facilitates dedicated immune recognition of human keratinocytes (Spreu 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS