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FLASH GENE
Symbol CLEC2A contributors: mct/npt - updated : 29-03-2010
HGNC name C-type lectin domain family 2, member A
HGNC id 24191
Location 12p13.31      Physical location : 10.065.825 - 10.084.980
Synonym name
  • proliferation-induced lymphocyte-associated receptor
  • INPE5792
  • keratinocyte-associated C-type lectin
  • Synonym symbol(s) UNQ5792, INPE5792, PILAR, KACL
    DNA
    TYPE functioning gene
    SPECIAL FEATURE tail to tail
    text positioned just approximately 3 kb centromeric from the KLRF2 gene in a tail-to-tail orientation (Spreu 2010)
    STRUCTURE 19.15 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text alternative splicing of exon 2 and of two distinct terminal exons (exon 5A/B), respectively, gives rise to four CLEC2A variants differing in the usage of the transmembrane domain and/or in the C-terminal portion of the CTL domain (Spreu 2007)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 916 - 174 - Huarte (2008)
    - - - - - - Spreu (2007)
  • also called CLEC2A1 variant
  • readily expressed at the cell surface, where it may serve as a ligand for NKC-encoded NK receptors
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skin/Tegumentskin    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage primarily in myeloid cell lineages, but not in epithelial cell lineages
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-type lectin (CTL) or carbohydrate-recognition domain, most similar to the CTLD of LLT1 (Spreu 2007)
  • HOMOLOGY
    Homologene
    FAMILY
  • C-type lectin domain family 2
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • induces apoptotic death on naive and early activated T cells if CD161 engagement is blocked (Huarte 2008)
  • potential role in the pathogenesis of joint inflammation (Huarte 2008)
  • non–disulfide-linked homodimeric surface receptor that stimulates cytotoxicity (Spreu 2010)
  • plays a central role in modulating the extent of T-cell expansion (Huarte 2008)
  • non-disulfide-linked homodimeric surface receptor, unique NKC-encoded receptor-ligand system that may fulfill a dedicated function in the immunobiology of human skin (Spreu 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interaction of C-type lectin-like receptors KLRF2 and CLEC2A facilitates dedicated immune recognition of human keratinocytes (Spreu 2010)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS