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FLASH GENE
Symbol CLEC1B contributors: mct - updated : 27-05-2014
HGNC name C-type lectin domain family 1, member B
HGNC id 24356
Location 12p13.31      Physical location : 10.145.663 - 10.151.899
Synonym name C-type lectin-like receptor-2
Synonym symbol(s) CLEC2, CLECSF2R, CLEC2B, PRO1384, QDED721, CLEC-2, 1810061I13Rik
DNA
TYPE functioning gene
STRUCTURE 6.24 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
regionally located probably localized to the NK-cell complex at 12p13 with the CD94, NKG2D, and OLR1 genes
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 982 - 229 - 2007 17616532
5 - 883 - 196 - 2007 17616532
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   predominantly
Lymphoid/Immunelymph node    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmegakaryocyte Homo sapiens
Blood/Hematopoieticplatelet Homo sapiens
Lymphoid/Immunedendritic cell Homo sapiens
Lymphoid/Immunenatural killer Homo sapiens
cell lineage
cell lines myeloid cells line
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one C-type lectin domain
  • cytosolic YXXL downstream of three acidic AAs in a sequence known as a hemITAM (hemi-immunoreceptor tyrosine-based activation motif)
  • conjugated GlycoP , PhosphoP
    mono polymer homomer , monomer , dimer
    HOMOLOGY
    Homologene
    FAMILY C-type lectin receptors family
    CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text expressed on platelets
    basic FUNCTION
  • having sugar binding activity
  • physiological target protein of podoplanin (PDPN) and imply that it is involved in podoplanin-induced platelet aggregation, tumor metastasis, and other cellular responses related to PDPN
  • with SYK, are essential for development in the megakaryocytic/platelet lineage
  • megakaryocyte/platelet expression of CLEC1B and SYK is required for normal brain vasculature and lymphatic development
  • plays crucial roles in thrombosis/hemostasis, tumor metastasis, and lymphangiogenesis
  • regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells
  • GP6 and CLEC1B can be simultaneously downregulated in platelets, suggesting an unexpected functional redundancy of the 2 receptors in hemostasis and thrombosis
  • acts as a cell-surface receptor for snake venom toxin rhodocytin and tumor antigen podoplanin
  • is required for development and maintenance of lymph nodes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • exisiting as non-disulfide-linked homodimer or monomer
  • dimerization of two phosphorylated CLEC1B molecules leads to recruitment of the tyrosine kinase SYK via its tandem SH2 domains and initiation of a downstream signaling cascade
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • podoplanin is a ligand for CLEC1B on renal cells
  • associating with GNB2L1, leading to CLEC1B ubiquitin-proteasome degradation
  • activates platelets through SRC and SYK tyrosine kinases, leading to tyrosine phosphorylation of downstream adapter proteins and effector enzymes, including PLCG2
  • CLEC1B acts as a SYK-coupled C-type lectin receptors (CLR) able to modulate TLR signaling and inflammatory responses
  • CLEC1B signals through a pathway that is critically dependent on the tyrosine kinase SYK
  • natural ligand/receptor for PDPN, in the formation of the lymphatic vasculature
  • cell & other
  • HIV-1 attachment factor
  • REGULATION
    activated by PDPN that rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces
    Phosphorylated by SYK (SYK mediates phosphorylation of the CLEC1B hemITAM receptor with SRC family kinases playing a critical role further downstream through the regulation of SYK and other effector proteins)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Clec-2-deficiency is lethal at mouse embryonic/neonatal stages associated with blood-filled lymphatics, indicating that Clec-2 is essential for blood/lymphatic vessel separation