basic FUNCTION
| having sugar binding activity |
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physiological target protein of podoplanin (PDPN) and imply that it is involved in podoplanin-induced platelet aggregation, tumor metastasis, and other cellular responses related to PDPN |
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with SYK, are essential for development in the megakaryocytic/platelet lineage |
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megakaryocyte/platelet expression of CLEC1B and SYK is required for normal brain vasculature and lymphatic development |
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plays crucial roles in thrombosis/hemostasis, tumor metastasis, and lymphangiogenesis |
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regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells |
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GP6 and CLEC1B can be simultaneously downregulated in platelets, suggesting an unexpected functional redundancy of the 2 receptors in hemostasis and thrombosis |
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acts as a cell-surface receptor for snake venom toxin rhodocytin and tumor antigen podoplanin |
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is required for development and maintenance of lymph nodes |