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FLASH GENE
Symbol CLEC12B contributors: KTN/npt - updated : 09-07-2008
HGNC name C-type lectin domain family 12, member B
HGNC id 31966
Location 12p13.2      Physical location : 10.163.230 - 10.171.399
Synonym name macrophage antigen H
Synonym symbol(s) UNQ5782
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     5 Exon(s)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3029 26 232 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  predominantly
Respiratorylung   lowly
Skin/Tegumentskin   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-type lectin domain
  • conjugated GlycoP , PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to dog CLEC12B (80.6 pc)
    homolog to murine Clec12b (73 pc)
    Homologene
    FAMILY
  • C-type lectin-like family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type II membrane protein
    basic FUNCTION
  • playing a role of cell surface receptor protecting target cells against natural killer cell-mediated lysis
  • modulating signaling cascades
  • mediating tyrosine phosphorylation of target MAP kinases
  • acting as an inhibitory receptor on myeloid cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PTPN6 and PTPN11
  • cell & other
  • binding to sugar
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS