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FLASH GENE
Symbol CLDND1 contributors: mct - updated : 07-06-2018
HGNC name claudin domain containing 1
HGNC id 1322
Location 3q11.2      Physical location : 98.234.317 - 98.241.910
Synonym name
  • chromosome 3 open reading frame 4
  • membrane protein GENX-3745
  • claudin-25
  • Synonym symbol(s) HSPC174, GENX-3745, C3orf4, PRO6000
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     5 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   HRE
    text structure
  • promoter contains a putative response element for retinoic acid receptor-related orphan receptor alpha (RORA)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1883 - 158 - 2017 28130419
    5 - 2188 - 253 - 2017 28130419
    5 - 2193 - 253 - 2017 28130419
    5 - 2237 - 276 - 2017 28130419
    6 - 2244 - 253 - 2017 28130419
    5 - 2500 - 253 - 2017 28130419
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainbasal nucleicorpus callosum  
     brainhindbraincerebellum highly Mus musculus
     spinal cord    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralwhite matter  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments
  • prokaryotic membrane, lipid attachment site
  • conjugated LipoP
    HOMOLOGY
    interspecies ortholog to murine 1110019C08Rik
    Homologene
    FAMILY
  • PMP-22/EMP/MP20 family
  • claudin family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm
    text
  • localizes to TJs and the cytoplasm
  • basic FUNCTION
  • potentially involved in the myelination process
  • is a novel survival factor in basal-like breast cancer cell lines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RORA interacts with the CLDND1 promoter to enhance transcription, and CLDND1 is a direct RORA target
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS