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FLASH GENE
Symbol CLDN8 contributors: mct/npt - updated : 16-06-2008
HGNC name claudin 8
HGNC id 2050
Location 21q22.11      Physical location : 31.586.324 - 31.588.469
Synonym name clostridium perfringens enterotoxin receptor
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1989 24.7 225 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea  
 earinnervestibule  
Urinarykidneytubulecollecting duct   Homo sapiens
 kidneynephronrenal capsule   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell
Hearing / Equilibriumcochlea cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four putative transmembrane segments
  • HOMOLOGY
    Homologene
    FAMILY
  • claudin family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text integral membrane protein
    basic FUNCTION
  • tight junction specific obliteration of the intercellular space
  • creating charge specific channels in the paracellular space
  • with CLDN7, are tight junction proteins expressed in distal nephron epithelium
  • interaction with CLDN4 are required for the anion-selective paracellular channel in the collecting duct
  • with CLDN4 are required for paracellular reabsorption of Cl–, interacted in cell membranes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major structural components of tight junction (TJ) strands
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in the collecting duct cells, the assembly of CLDN4 into tight junctions strands required its interaction with CLDN8
  • interacted strongly with CLDN3 and CLDN7, normal TJ constituents in the collecting duct
  • cell & other
    REGULATION
    Other potentially developmentally regulated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal cancer (Groene 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma
    Therapy target
    ANIMAL & CELL MODELS