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FLASH GENE
Symbol CLDN7 contributors: mct - updated : 11-03-2011
HGNC name claudin 7
HGNC id 2049
Location 17p13.1      Physical location : 7.163.222 - 7.166.512
Synonym name
  • clostridium perfringens enterotoxin receptor-like 2
  • Synonym symbol(s) CPETRL2, CEPTRL2, claudin-1
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 3.29 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1462 - 211 - 1997 9441748
    3 - 1944 - 145 - 1997 9441748
    4 - 2029 - 211 - 1997 9441748
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestinecolon predominantly
     pancreas exocrine   moderately
     stomach   moderately
    Endocrineparathyroid   moderately
    Lymphoid/Immunelymph node   moderately
    Reproductivefemale systemplacenta  moderately
     female systemovary  highly
    Respiratorylung   moderately
    Urinarykidneytubulecollecting duct   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four putative transmembrane segments
  • HOMOLOGY
    interspecies homolog to murine Cldn7 (91.9pc)
    Homologene
    FAMILY
  • claudin family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text
  • CLDN7 colocalized with EPCAM at cell-cell junctions, and the two proteins were found to associate with each other
  • basic FUNCTION
  • playing a major role in tight junction specific obliteration of the intercellular space
  • creating charge specific channels in the paracellular space
  • regulate the integrity and function of tight junctions and influence tumorigenesis
  • with CLDN8, are tight junction proteins expressed in distal nephron epithelium
  • inhibits cell migration and invasion through ERK/MAPK signaling pathway in response to growth factor stimulation in lung cancer cells
  • EPCAM and its associated protein, CLDN7, play a critical role in reprogramming
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major structural components of tight junction (TJ) strands
  • an EPCAM-CLDN7 complex, rather than EPCAM itself, can promote proliferation, apoptosis resistance, migration, and tumorigenicity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TJP1/ZO-1
  • TJP2/ZO-2
  • TJP3/ZO-3
  • induction by ELF3 appears critical to the formation of the epithelial structures in biphasic synovial sarcoma
  • interacted strongly with CLDN3 and CLDN7, normal TJ constituents in the collecting duct
  • EPCAM bound tightly to CLDN7 (CLDN7 was required for association of CLDN1 with EPCAM)
  • cell & other
    REGULATION
    induced by androgens
    TSLP (TSLP induces expression of CLDN7 in dendritic cells (DCs) via NF-kappaB as well as via TLRs and may control tight junctions of DCs to preserve the epithelial barrier during allergic inflammation)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    frequently up-regulated in gastric adenocarcinoma
    tumoral     --other  
    expression tightly associated with epithelial structures in synovial sarcomas
    tumoral     --low  
    might lead to venous invasion and liver metastasis in colorectal cancer, and reduced expression of CLDN7 may thus be a useful predictor of liver metastasis in patients with colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma
  • Therapy target
    ANIMAL & CELL MODELS