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FLASH GENE
Symbol CLDN6 contributors: mct/npt - updated : 16-06-2008
HGNC name claudin 6
HGNC id 2048
Location 16p13.3      Physical location : 3.064.713 - 3.068.188
Synonym name
  • clostridium perfringens enterotoxin receptor
  • skullin 2
  • DNA
    TYPE functioning gene
    STRUCTURE 3.48 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1389 23.2 220 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text early expression in stem cells of epithelium
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four putative transmembrane segments
  • HOMOLOGY
    Homologene
    FAMILY
  • claudin family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text integral membrane protein
    basic FUNCTION
  • tight junction specific obliteration of the intercellular space
  • creating charge specific channels in the paracellular space
  • Ca2+ independent cell adhesion activity
  • able to mediate the entry of HCV into target cells (Zheng 2007)
  • with CLDN1 and CLDN9, are entry cofactors for hepatitis C virus HCV (Meertens 2008)
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text epithelialization
    PATHWAY
    metabolism
    signaling
    a component
  • major structural components of tight junction (TJ) strands
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by BMP signaling pathway
    inhibited by noggin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    silencing by methylation in esophageal squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS