Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CLDN18 contributors: mct/npt/pgu - updated : 09-07-2012
HGNC name claudin 18
HGNC id 2039
Location 3q22.3      Physical location : 137.717.657 - 137.752.494
Synonym name
  • surfactant associated protein J
  • surfactant associated 5
  • Synonym symbol(s) SFTA5, SFTPJ
    DNA
    TYPE functioning gene
    STRUCTURE 34.84 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    alternative promoter
    text structure two alternative promoters
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 3359 27.9 261 lung-tissue specific 2011 21571049
  • CLDN18.1
  • 5 splicing 3350 27.9 261 . expression in normal tissues is strictly confined to differentiated epithelial cells of the gastric mucosa, but it is absent from the gastric stem cell zone . strict restriction to one cell lineage 2011 21571049
  • frequent ectopic activation in a diversity of cancers, and ability to specifically target this molecule at the cell surface of tumor cells
  • highly attractive pan-cancer target for the antibody therapy of epithelial tumors
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly Homo sapiens
     stomach   highly Homo sapiens
    Hearing/Equilibriumearinnercochlea  
     earinnervestibule  
    UrinarykidneytubuleHenles loopHL ascending limbhighly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell Homo sapiens
    Hearing / Equilibriumcochlea cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments
  • a binding site of the transcription factor cyclic AMP-responsive element binding protein (CREB)
  • HOMOLOGY
    interspecies ortholog to murine Cldn18
    homolog to Xenopus Xl.9841
    homolog to C.elegans C18D11.1
    Homologene
    FAMILY
  • claudin family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text
  • integral membrane proteins of the tight junction, a structure that seals off the intercellular space between adjacent epithelial cells and regulates passive diffusion of solutes and macromolecules
  • basic FUNCTION
  • tight junction specific obliteration of the intercellular space
  • creating charge specific channels in the paracellular space
  • dominant tight junction protein in Barrett esophagus and likely contributor to its acid resistance
  • plays a key role in constructing tight junctions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major structural components of tight junction (TJ) strands
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other target gene for the homeodomain transcription factor NKX2.1 (TITF1)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    predominantly expressed in lung adenocarcinomas and in tumors of nonsmokers
    tumoral     --other  
    primarily regulated at the transcriptional level via specific PRKC signaling pathways and modified by DNA methylation
    tumoral     --over  
    in ulcerative colitis
    tumoral     --other  
    its expression correlates with poor survival in patients with CRC and is associated with the gastric phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • associated with a better survival in lung adenocarcinoma and had an independent prognostic value and may thus be used in the evaluation of patient prognosis
  • marker for the early carcinogenetic process, is commonly expressed in precursor lesions of pancreatic ductal adenocarcinomas
  • Therapy target
    ANIMAL & CELL MODELS