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FLASH GENE
Symbol CLDN10 contributors: mct/npt - updated : 30-09-2015
HGNC name claudin 10
HGNC id 2033
Location 13q32.1      Physical location : 96.085.852 - 96.232.010
Synonym name
  • clostridium perfringens enterotoxin receptor
  • OSP-like protein
  • Synonym symbol(s) OSP-L, CPETRL3
    DNA
    TYPE functioning gene
    STRUCTURE 146.16 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GPC6 13q32 glypican 6 DCT 13q32 dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) TGDS 13q32.1 TDP-glucose 4,6-dehydratase ITR 13q32.1 intimal thickness-related receptor SOX21 13q31-q32 SRY (sex determining region Y)-box 21 LOC387941 13 LOC387941 LOC341583 13q32.1 similar to bromodomain containing 7; bromodomain protein; bromodomain-containing 7 LOC387942 13 LOC387942 ABCC4 13q31 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 CLDN10 13q31-q34 claudin 10 DZIP1 13q32.1 claudin 10 DNAJC3 13q32 DnaJ (Hsp40) homolog, subfamily C, member 3 UGCGL2 13q32.1 UDP-glucose ceramide glucosyltransferase-like 2 HS6ST3 13 heparan sulfate 6-O-sulfotransferase 3 LOC283476 13q32.2 hypothetical protein LOC283476 LOC390420 13 similar to heat shock protein 84 - mouse LOC341592 13q32.2 similar to tubby like protein 3 GPR80 13q32.2 G protein-coupled receptor 80 MBNL2 13q31.1 muscleblind-like 2 (Drosophila) RAP2A 13q34 RAP2A, member of RAS oncogene family LOC121906 13q32.2 similar to Proteasome subunit alpha type 6 (Proteasome iota chain) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (27 kDa prosomal protein) (PROS-27) (p27K) LOC387943 13 LOC387943
    RNA
    TRANSCRIPTS type messenger
    text alternative splicing of CLDN10 generates unique permselectivities and might contribute to the variable paracellular transport observed along the nephron (PMID: 16804102)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2601 - 207 - 2009 19383724
  • isoform a_i1
  • 5 - 2658 24.3 228 widely expressed among tissues including the kidney, is enriched in the medullary region 2009 19383724
  • isoform b
  • - - 2658 - 226 is unique to the kidney, found predominantly in cortical segments 2009 19383724
  • isoform a
  • - splicing - - - - 2009 19383724
  • results from an alternative splice donor site, causing a deletion of the last 57 nucleotides of exon 1a
  • - splicing - - - - 2009 19383724
  • lacking exon 4
  • - splicing - - - - 2009 19383724
  • lacking exon 4
  • - splicing - - - - 2009 19383724
  • lacking exon 4
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea   Homo sapiens
    Reproductivefemale systemuterus    Homo sapiens
     male systemmale genital tractepididymis   Homo sapiens
    UrinarykidneytubuleHenles loopHL ascending limb  Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningendometrium   Homo sapiens
    Epithelialsensorystato-auditory   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumcochlea cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four putative transmembrane segments
  • HOMOLOGY
    Homologene
    FAMILY
  • claudin family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm
    text integral membrane protein
    basic FUNCTION
  • tight junction specific obliteration of the intercelular space
  • creating charge specific channels in the paracellular space
  • determines paracellular sodium permeability
  • is a key factor in control of cation selectivity and transport in the thick ascending limb (TAL)
  • is crucial to paracellular Na+ handling in the TAL, and its absence leads to a shift from paracellular sodium transport to paracellular hyperreabsorption of Ca2+ and Mg2+
  • role for CLDN10 during the transmission of laterality information from Hensen node to both the left and right sides of the embryo
  • role of CLDN3 and CLDN10 in decidual angiogenesis and regulation of trophoblast invasion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major structural components of tight junction (TJ) strands
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other expression of CLDN10 may be regulated by the FOS pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of CLDN1 and CLDN10 indicates a favorable prognosis for overall survival in some patients with lung adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in isolated perfused thick ascending limb tubules of claudin-10–deficient mice, paracellular permeability of sodium is decreased, and the relative permeability of calcium and magnesium is increased, and its loss leads to hypermagnesemia and nephrocalcinosis