SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,chromatin/chromosome,centromere
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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| text
| colocalizing with CLIPs at microtubule distal ends |
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during mitosis, it localizes to centrosomes, the mitotic spindle, centrosomeres and spindle midzone |
| basic FUNCTION
| orientation of stabilized microtubules and attachment to kinetochore |
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involved in local regulation of microtubule dynamics |
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playing a role in centrosome separation, organization and maintenance of the bipolar mitotic spindle |
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cooperate with CLASP1 to ensure mitotic fidelity by regulating spindle and kinetochore function |
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required for mitotic spindle organization and kinetochore alignment  |
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function as actin/microtubule crosslinkers in interphase cells and facilitate recognition of actin filaments by the plus ends of growing microtubules at the initial stages of actin-microtubule interaction |
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essential for Golgi-associated microtubule nucleation and directional migration |
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CLASP2 and NEK1 proteins are present in a centrosomal complex and participate in cell cycle and cell division mechanisms |
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role in insulin action, where CLASP2 directs the delivery of SLC2A4 to cell cortex landing zones important for insulin action |
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microtubule plus-end tracking protein CLASP2 is a key regulator of axon and dendrite outgrowth that leads to functional alterations in synaptic activity and formation |
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during mitosis the kinetochore (KT)-microtubule (MT)-associated protein CLASP2 is progressively and distinctively phosphorylated by CDK1 and PLK1 kinases, concomitant with the establishment of KT-MT attachments |
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involvement of the microtubule plus-end tracking protein CLASP2 in cytoskeleton-related mechanisms underlying neuronal polarity and interplay between microtubule stabilization and synapse formation and activity |
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CLASP2-mediated stabilization of microtubules is required for proper attachment, homing, and maintenance of hematopoietic stem cells, and this is necessary to sustain MPL transcription |
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both GSK3B-dependent phosphorylation and the level of CLASP2 play a role in the maintenance of CHRNA1 cluster size through the regulated capture and release of Microtubule plus-ends |
