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Symbol CLASP2 contributors: npt/shn/pgu - updated : 09-12-2015
HGNC name cytoplasmic linker associated protein 2
HGNC id 17078
Location 3p22.3      Physical location : 33.537.740 - 33.759.848
Synonym name
  • cDNA sequence,expressed in brain, >100kDa, similar to KIAA0622 related to C elegans 117.3 kDa protein
  • CLIP-associating protein 2
  • multiple asters (Mast)-like homolog 2
  • protein Orbit homolog 2
  • Synonym symbol(s) KIAA0627, hOrbit2
    TYPE functioning gene
    STRUCTURE 222.11 kb     38 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D3S2432 - D3S4525 - CLASP2 - D3S3518 - D3S1619 - cen
    Physical map
    SIMP 3p22.3 source of immunodominant MHC-associated peptides OSBPL10 3p22.3 oxysterol binding protein-like 10 LOC344787 3p22.3 similar to KIAA2033 protein KIAA0089 3p22.3 similar to KIAA2033 protein LOC391525 3 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) CKLFSF8 3p22.3 chemokine-like factor super family 8 CKLFSF7 3p22.3 chemokine-like factor super family 7 CKLFSF6 3p22.3 chemokine-like factor super family 6 LOC285260 3p22.3 similar to ribosomal protein L31 DNCLI1 3p22.2 dynein, cytoplasmic, light intermediate polypeptide 1 LOC391526 3 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) CNOT10 3p22.3 CCR4-NOT transcription complex, subunit 10 LOC389101 3 similar to 60S ribosomal protein L23a LOC389102 3 similar to YPLR6490 LOC131405 3p22.3 similar to abnormal cell LINeage LIN-41, heterochronic gene; Drosophila dappled/ vertebrate TRipartite Motif protein related; B-box zinc finger, Filamin and NHL repeat containing protein (123.8 kD) (lin-41) CCR4 3p24 chemokine (C-C motif) receptor 4 LOC389103 3 LOC389103 GLB1 3p21.33 galactosidase, beta 1 CRTAP 3p22 cartilage associated protein KIAA0527 3p22.3 KIAA0527 protein FBXL2 3p24.3 F-box and leucine-rich repeat protein 2 UBP1 3p22.2 upstream binding protein 1 (LBP-1a) CLASP2 3p24.2-p21.33 cytoplasmic linker associated protein 2 LOC389104 3 similar to CLIP-associating protein 1; multiple asters 1 PDCD6IP 3p22.3 programmed cell death 6 interacting protein LOC285307 3p22.2 hypothetical LOC285307 FECHP 3p23-p22 ferrochelatase pseudogene LOC389105 3 LOC389105
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    38 splicing 7289 165 1506 - 2007 17342765
    - - 6733 - 1294 - 2007 17342765
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain   highly
    Visualeye   highly
    cell lineage
    cell lines
    at STAGE
  • four heat repeats
  • microtubule-binding domain of CLASP2 (which is homologous between all CLASPs)
  • the N-terminal dis1/TOG domain of CLASP2alpha (which is homologous between alpha isoforms) possess actin-binding activity
  • secondary structure
  • two TOG domains of CLASP2 consisting of six HEAT repeats, which are similar to the canonical paddle-like tubulin-binding TOG domains, but have arched conformations
    interspecies ortholog to Clasp2, Rattus norvegicus
    ortholog to Clasp2, Mus musculus
    ortholog to clasp2, Danio rerio
    ortholog to CLASP2, Pan troglodytes
    intraspecies paralog to CLASP1
  • CLASP family
  • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
  • colocalizing with CLIPs at microtubule distal ends
  • during mitosis, it localizes to centrosomes, the mitotic spindle, centrosomeres and spindle midzone
  • basic FUNCTION
  • orientation of stabilized microtubules and attachment to kinetochore
  • involved in local regulation of microtubule dynamics
  • playing a role in centrosome separation, organization and maintenance of the bipolar mitotic spindle
  • cooperate with CLASP1 to ensure mitotic fidelity by regulating spindle and kinetochore function
  • required for mitotic spindle organization and kinetochore alignment
  • function as actin/microtubule crosslinkers in interphase cells and facilitate recognition of actin filaments by the plus ends of growing microtubules at the initial stages of actin-microtubule interaction
  • essential for Golgi-associated microtubule nucleation and directional migration
  • CLASP2 and NEK1 proteins are present in a centrosomal complex and participate in cell cycle and cell division mechanisms
  • role in insulin action, where CLASP2 directs the delivery of SLC2A4 to cell cortex landing zones important for insulin action
  • microtubule plus-end tracking protein CLASP2 is a key regulator of axon and dendrite outgrowth that leads to functional alterations in synaptic activity and formation
  • during mitosis the kinetochore (KT)-microtubule (MT)-associated protein CLASP2 is progressively and distinctively phosphorylated by CDK1 and PLK1 kinases, concomitant with the establishment of KT-MT attachments
  • involvement of the microtubule plus-end tracking protein CLASP2 in cytoskeleton-related mechanisms underlying neuronal polarity and interplay between microtubule stabilization and synapse formation and activity
  • CLASP2-mediated stabilization of microtubules is required for proper attachment, homing, and maintenance of hematopoietic stem cells, and this is necessary to sustain MPL transcription
  • both GSK3B-dependent phosphorylation and the level of CLASP2 play a role in the maintenance of CHRNA1 cluster size through the regulated capture and release of Microtubule plus-ends
    a component
  • AKAP11 serves as a platform for the assembly of a CLASP2-IQGAP sub-complex
    small molecule
  • CLIP2 and CLIP1, binding to microtubules and cooperate to direct the microtubule network and regulating cellular asymmetry
  • association with the kinetochores relies on its C-terminal domain, but is independent of microtubules or association with CLIP1
  • MAPRE1
  • estrogen receptor binding CpG island, EB1
  • CLASP2 interaction with IQGAP1 (interacts with IQGAP1 preferentially when calcium levels are increased)
  • the cascade linking AGRN to CLASP2-mediated microtubule capturing at the synaptic membrane is essential for the maintenance of a normal neuromuscular phenotype
  • role for the scaffolding protein EPB41 in locally controlling CLASP2 behavior, CLASP2 cortical platform turnover and GSK3 activity, enabling correct microtubule organization and dynamics essential for cell polarity
  • interacts with CTNND1 and governs microtubule dynamics at adherens junctions
  • functional relationship between ABL1 and CLASP2 is conserved and provides a means to control the CLASP2 association with the cytoskeleton
  • CLASP2 directly interacted with PARD3 and was phosphorylated by PRKCI
  • transport system, organized by AGRN through PI3 kinase, GSK3B, CLASP2, and PHLDB2, for precise delivery of CHRNA1 vesicles from the subsynaptic nuclei to the overlying synaptic membrane
  • cell & other
    Phosphorylated by CDK1, PLK1
    corresponding disease(s)
    Variant & Polymorphism
    Candidate gene
    Therapy target
  • primary fibroblasts from Clasp2 knockout mice show numerous spindle and chromosome segregation defects that can be partially rescued by ectopic expression of Clasp1 or Clasp2