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FLASH GENE
Symbol CLASP1 contributors: npt/shn/pgu - updated : 08-04-2010
HGNC name cytoplasmic linker associated protein 1
HGNC id 17088
Location 2q14.3      Physical location : 122.095.353 - 122.407.052
Synonym name
  • CLIP-associating protein 1
  • Drosophila "multiple asters" (Mast)-like homolog 1
  • multiple asters 1
  • cDNA sequence,expressed in brain, >100kDa, related to hypothetical C elegans 117.3 kDa protein
    • Synonym symbol(s) KIAA0622, FLJ33821, FLJ41222, MAST1, MGC131895, DKFZp686D1968, DKFZp686H2039, hOrbit1
    DNA
    TYPE functioning gene
    STRUCTURE 311.70 kb     39 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D2S2265 - D2S2258 - CLASP1 - D2S343 - D2S2353 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    39 splicing 7941 - 1479 - 2003 12837247
    38 splicing 7917 - 1471 - 2003 12837247
    39 splicing 8118 - 1538 - 2003 12837247
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivemouth   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Reproductivefemale systembreastmammary gland highly
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six heat repeats
    • HOMOLOGY
    interspecies ortholog to clasp1, Danio rerio
    ortholog to Clasp1, Mus musculus
    ortholog to CLASP1, Pan troglodytes
    ortholog to Clasp1, Rattus norvegicus
    intraspecies homolog to CLASP2
    Homologene
    FAMILY
  • CLASP family
    • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • colocalized with CLIPs at microtubule distal ends
  • during the mitosis, it localizes to centrosomes, the mitotic spindle, centromeres and spindle midzone
    • basic FUNCTION
  • local regulation spindle microtubule dynamics and attachment to kinetochore
  • plays a role in centrosome separation and organisation of the bipolar mitotic spindle
  • required at kinetochores for attached microtubules to exhibit normal dynamic behavior
  • cooperate with CLASP2 to ensure mitotic fidelity by regulating spindle and kinetochore function
  • required for mitotic spindle organization and kinetochore alignment
  • function as actin/microtubule crosslinkers in interphase cells and facilitate recognition of actin filaments by the plus ends of growing microtubules at the initial stages of actin-microtubule interaction
  • essential for Golgi-associated microtubule nucleation and directional migration
  • CLASP1 is required to correctly capture astral microtubules, whereas MAP4 prevents engagement of excess dynein motors, thereby protecting the system from force imbalance
  • MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis in human cells
    • CELLULAR PROCESS cell cycle, division
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CLIP2 and CLIP1, binding to microtubules and cooperate to direct the microtubule network and regulating cellular asymmetry
  • MAPRE1
  • interacting with GSK3A (controls axon growth via CLASP1-mediated regulation of growth cone microtubules)
  • estrogen receptor binding CpG island, EB1
  • PRC1 to the central spindle at early anaphase onset
  • is a substrate for the BRCA1, suggesting that its modification selectively triggers CHEK1 activation for the homology-directed repair of a subset of genotoxic lesions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS