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FLASH GENE
Symbol CLASP1 contributors: npt/shn/pgu - updated : 08-04-2010
HGNC name cytoplasmic linker associated protein 1
HGNC id 17088
Location 2q14.3      Physical location : 122.095.353 - 122.407.052
Synonym name
  • CLIP-associating protein 1
  • Drosophila "multiple asters" (Mast)-like homolog 1
  • multiple asters 1
  • cDNA sequence,expressed in brain, >100kDa, related to hypothetical C elegans 117.3 kDa protein
  • Synonym symbol(s) KIAA0622, FLJ33821, FLJ41222, MAST1, MGC131895, DKFZp686D1968, DKFZp686H2039, hOrbit1
    DNA
    TYPE functioning gene
    STRUCTURE 311.70 kb     39 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D2S2265 - D2S2258 - CLASP1 - D2S343 - D2S2353 - qter
    Physical map
    DDX18 2q13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 LOC389024 2 LOC389024 LOC343958 2q14.2 similar to 5-HT5B serotonin receptor FLJ10996 2q14.2 hypothetical protein FLJ10996 INSIG2 2q21.2 insulin induced gene 2 LOC389025 2 LOC389025 LOC151154 2q14.2 hypothetical LOC151154 EN1 2q14.2 engrailed homolog 1 MARCO 2q14.2 macrophage receptor with collagenous structure LOC165257 2q14.2 C1q-domain containing protein TSAP6 2q14.2 C1q-domain containing protein LOC389026 2 similar to PRO1546 DBI 2q12-q21 diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein) PR1 2q14.2 voltage-dependent calcium channel gamma subunit-like protein SCTR 2q14.1 secretin receptor LOC200373 2q14.2 similar to hypothetical protein MGC10993 2q14.2 hypothetical protein MGC10993 PTPN4 2p24.3-p24.1 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) EPB41L5 2q21.2 erythrocyte membrane protein band 4.1 like 5 LOC391431 2 similar to NADH dehydrogenase subunit 5 FAM11B 2q21.2 similar to NADH dehydrogenase subunit 5 RALB 2cen-q13 v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) INHBB 2q12-q13 inhibin, beta B (activin AB beta polypeptide) FLJ14816 2q14.2 hypothetical protein FLJ14816 GLI2 2q24 GLI-Kruppel family member GLI2 TFCP2L1 2q14 transcription factor CP2-like 1 CLASP1 2q14-q21 cytoplasmic linker associated protein 1 MKI67IP 2q14.3 MKI67 (FHA domain) interacting nucleolar phosphoprotein TSN 2q21.1 translin LOC389027 2 LOC389027 LOC389028 2 LOC389028 caspr5 2q14.3 caspr5 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    39 splicing 7941 - 1479 - 2003 12837247
    38 splicing 7917 - 1471 - 2003 12837247
    39 splicing 8118 - 1538 - 2003 12837247
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivemouth   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Reproductivefemale systembreastmammary gland highly
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six heat repeats
  • HOMOLOGY
    interspecies ortholog to clasp1, Danio rerio
    ortholog to Clasp1, Mus musculus
    ortholog to CLASP1, Pan troglodytes
    ortholog to Clasp1, Rattus norvegicus
    intraspecies homolog to CLASP2
    Homologene
    FAMILY
  • CLASP family
  • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • colocalized with CLIPs at microtubule distal ends
  • during the mitosis, it localizes to centrosomes, the mitotic spindle, centromeres and spindle midzone
  • basic FUNCTION
  • local regulation spindle microtubule dynamics and attachment to kinetochore
  • plays a role in centrosome separation and organisation of the bipolar mitotic spindle
  • required at kinetochores for attached microtubules to exhibit normal dynamic behavior
  • cooperate with CLASP2 to ensure mitotic fidelity by regulating spindle and kinetochore function
  • required for mitotic spindle organization and kinetochore alignment
  • function as actin/microtubule crosslinkers in interphase cells and facilitate recognition of actin filaments by the plus ends of growing microtubules at the initial stages of actin-microtubule interaction
  • essential for Golgi-associated microtubule nucleation and directional migration
  • CLASP1 is required to correctly capture astral microtubules, whereas MAP4 prevents engagement of excess dynein motors, thereby protecting the system from force imbalance
  • MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis in human cells
  • CELLULAR PROCESS cell cycle, division
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CLIP2 and CLIP1, binding to microtubules and cooperate to direct the microtubule network and regulating cellular asymmetry
  • MAPRE1
  • interacting with GSK3A (controls axon growth via CLASP1-mediated regulation of growth cone microtubules)
  • estrogen receptor binding CpG island, EB1
  • PRC1 to the central spindle at early anaphase onset
  • is a substrate for the BRCA1, suggesting that its modification selectively triggers CHEK1 activation for the homology-directed repair of a subset of genotoxic lesions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS